Toxicity of intracellular amyloid-beta peptide and mitochondrial permeability transition pore
文献类型：期刊论文
| 作者 | ZHENG Chunyan; ZHANG Haiyan ; TANG Xican
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2008 |
| 卷号 | 20期号:4页码:593-598 |
| 关键词 | Alzheimer＇s disease amyloid-beta peptide mitochondria mitochondrial permeability transition pore |
| ISSN号 | 1004-0374 |
| 其他题名 | beta-淀粉样肽的细胞内毒性与线粒体通透性转变孔道 |
| 文献子类 | Article |
| 英文摘要 | Amyloid-beta （Abeta）, the main constituent of senile plaques in the brain of Alzheimer＇s disease （AD） patients, has been demonstrated to be neurotoxic both in vivo and in vitro. Recently, intracellular Abeta has been widely found to exert its neurotoxicity through multiple pathways. Accumulating studies, based on the isolated mitochondria, have reported that Abeta could induce the opening of mitochondrial permeability transition pore （MPTP）, aggravate mitochondrial dysfunction, and eventually result in the release of cytochrome c and apoptosisinducing-factor from mitochondria, which may underlie the mechanisms of intracellular Abeta induced neurotoxicity. Efforts on elucidating MPTP involvement in Abeta action are anticipated to be helpful to find new ways attenuating Abeta-induced neurotoxicity. |
| 资助项目 | 国家自然科学基金（30572169）[00000000] ; 国家973资助项目（2004CB518907）[00000000] |
| WOS研究方向 | Neurosciences & Neurology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3402444 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268082]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | TANG Xican |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHENG Chunyan,ZHANG Haiyan,TANG Xican. Toxicity of intracellular amyloid-beta peptide and mitochondrial permeability transition pore[J]. Chinese Bulletin of Life Sciences,2008,20(4):593-598. |
| APA | ZHENG Chunyan,ZHANG Haiyan,&TANG Xican.(2008).Toxicity of intracellular amyloid-beta peptide and mitochondrial permeability transition pore.Chinese Bulletin of Life Sciences,20(4),593-598. |
| MLA | ZHENG Chunyan,et al."Toxicity of intracellular amyloid-beta peptide and mitochondrial permeability transition pore".Chinese Bulletin of Life Sciences 20.4(2008):593-598. |
入库方式： OAI收割
来源：上海药物研究所
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