Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators
文献类型：期刊论文
| 作者 | LI Qunyi; YAN Jianhua; WANG Mingwei
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2008 |
| 卷号 | 20期号:5页码:800-806 |
| 关键词 | glucocorticoids receptor modulators |
| ISSN号 | 1004-0374 |
| 其他题名 | 糖皮质激素受体及其选择性调节剂研究进展 |
| 文献子类 | Article |
| 英文摘要 | Glucocorticoids （GCs） are widely used as anti-inflammatory therapeutics. Their physiological and pharmacological actions are mainly mediated by glucocorticoid receptor （GR）. As a member of the nuclear receptor superfamily, GR is a ligand-activated transcriptional factor and plays important roles in many physiological and pathological processes. With in-depth knowledge on the molecular mechanisms involved in GR- related signal transduction pathways, discovery of novel GR modulators has become one of the focal points in drug development, aiming at increasing efficacies and reducing side effects. In this review, we briefly describe the current understanding of molecular structure, biological functions and selective modulators of GR. |
| 资助项目 | 973计划（2004CB518902）[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3424041 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268083]  |
| 专题 | 国家新药筛选中心 科研与新药推进处 |
| 通讯作者 | WANG Mingwei |
| 作者单位 | The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LI Qunyi,YAN Jianhua,WANG Mingwei. Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators[J]. Chinese Bulletin of Life Sciences,2008,20(5):800-806. |
| APA | LI Qunyi,YAN Jianhua,&WANG Mingwei.(2008).Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators.Chinese Bulletin of Life Sciences,20(5),800-806. |
| MLA | LI Qunyi,et al."Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators".Chinese Bulletin of Life Sciences 20.5(2008):800-806. |
入库方式： OAI收割
来源：上海药物研究所
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