中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators

文献类型:期刊论文

作者LI Qunyi; YAN Jianhua; WANG Mingwei
刊名Chinese Bulletin of Life Sciences
出版日期2008
卷号20期号:5页码:800-806
关键词glucocorticoids receptor modulators
ISSN号1004-0374
其他题名糖皮质激素受体及其选择性调节剂研究进展
文献子类Article
英文摘要Glucocorticoids (GCs) are widely used as anti-inflammatory therapeutics. Their physiological and pharmacological actions are mainly mediated by glucocorticoid receptor (GR). As a member of the nuclear receptor superfamily, GR is a ligand-activated transcriptional factor and plays important roles in many physiological and pathological processes. With in-depth knowledge on the molecular mechanisms involved in GR- related signal transduction pathways, discovery of novel GR modulators has become one of the focal points in drug development, aiming at increasing efficacies and reducing side effects. In this review, we briefly describe the current understanding of molecular structure, biological functions and selective modulators of GR.
资助项目973计划(2004CB518902)[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:3424041
源URL[http://119.78.100.183/handle/2S10ELR8/268083]  
专题国家新药筛选中心
科研与新药推进处
通讯作者WANG Mingwei
作者单位The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714
LI Qunyi,YAN Jianhua,WANG Mingwei. Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators[J]. Chinese Bulletin of Life Sciences,2008,20(5):800-806.
APA LI Qunyi,YAN Jianhua,&WANG Mingwei.(2008).Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators.Chinese Bulletin of Life Sciences,20(5),800-806.
MLA LI Qunyi,et al."Research progresses in glucocorticoid receptor and selective glucocorticoid receptor modulators".Chinese Bulletin of Life Sciences 20.5(2008):800-806.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。