Metabolism and regulation of beta-amyloid: a potential target for Alzheimer therapy
文献类型：期刊论文
| 作者 | YAN Han; TANG Xican
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2007 |
| 卷号 | 19期号:4页码:409-416 |
| 关键词 | Alzheimer's disease P-amyloid neurotoxicity |
| ISSN号 | 1004-0374 |
| 其他题名 | beta-淀粉样蛋白的代谢与调控:阿尔采末病的潜在治疗靶点 |
| 文献子类 | Review |
| 英文摘要 | Being the main component of senile plaques in Alzheimer's disease (AD), P-amyloid protein (A0) is derived from amyloid precursor protein via P-secretase-mediated pathway. The neurotoxicity of Abeta has been proven by abundant studies, which can be intensified by aggregation. There is a homeostasis of A|3 production and clearance in the physiological state. Genetic mutation and environment can interrupt this balance and lead to assembly and deposition of Abeta in turn cause or accelerate the progress of AD, via oxidative stress, apoptosis, inflammation, etc. In this paper, the formation, clearance and neurotoxicity of Abeta as well as its possible role in AD are reviewed. |
| 资助项目 | 国家自然科学基金项目(30572169)[00000000] |
| WOS研究方向 | Neurosciences & Neurology ; Biochemistry & Molecular Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2912412 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268152]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | TANG Xican |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | YAN Han,TANG Xican. Metabolism and regulation of beta-amyloid: a potential target for Alzheimer therapy[J]. Chinese Bulletin of Life Sciences,2007,19(4):409-416. |
| APA | YAN Han,&TANG Xican.(2007).Metabolism and regulation of beta-amyloid: a potential target for Alzheimer therapy.Chinese Bulletin of Life Sciences,19(4),409-416. |
| MLA | YAN Han,et al."Metabolism and regulation of beta-amyloid: a potential target for Alzheimer therapy".Chinese Bulletin of Life Sciences 19.4(2007):409-416. |
入库方式： OAI收割
来源：上海药物研究所
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