Synthesis and iodine-radiolabelling of peripheral benzodiazepine receptor tracer ~(131)I-CLINDE
文献类型：期刊论文
| 作者 | Li Bin1; Li Jianfeng3 ; Wang Xuebin2; Huang Gang1
|
| 刊名 | Nuclear Techniques
 |
| 出版日期 | 2006 |
| 卷号 | 29期号:10页码:777-781 |
| 关键词 | (131)I Iodine-131 Imidazo[l,2-a]pyridines Synthesis Peripheral type benzodiazepine receptors (PBRs) Iododestannylation |
| ISSN号 | 0253-3219 |
| 其他题名 | 外周苯二氮卓受体示踪剂~(131)I-CLINDE的合成和标记 |
| 文献子类 | Article |
| 英文摘要 | This paper describes the preparation of N,N'-diethyl-6-chloro-(4'-iodophenyl)-imidazo-[l,2-a]pyridine-3-acetamide (CLINDE) and ~(131)I- labelled ([~(131)I]- CLINDE). Non-radioactive imidazo[l,2-a]pyridine wassynthesized by condensation of 5-chloro-2-aminopyridines with the bromo keto amides. Radiolabelling [~(131)I]-imidazo [l,2-a]pyridines was prepared by iododestannylation with Na[~(131)I] in the presence of peroxide of hydrogen and purified by Ci8 reverse phase HPLC. Non-radioactive imidazo-[1,2-a] pyridine was synthesized at a total yield of 30.8%. Radiolabelling [~(131)I]-imidazo [1,2-a]pyridines was prepared with a radiochemical yield of 80% and a radiochemical purity of greater than 98%. An improved, economical process is suited for preparing N, N'-diethyl-6-chloro-(4'-iodo-phenyl)-imidazo-[l,2-a]pyridine-3-acetainide and its radiosynthesis. |
| 资助项目 | 上海市卫生局计划项目[00000000] ; 上海市教委重点发展基金资助[00000000] |
| WOS研究方向 | Chemistry ; General & Internal Medicine ; Oncology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2429588 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268241]  |
| 专题 | 科研与新药推进处 |
| 作者单位 | 1.Department of Nuclear Medicine, Reiji Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200127, China.; 2.Department of Chemistry, Beijing Normal University, Beijing 100875, China. 3.Shangliai Institute ofMateria Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | Li Bin,Li Jianfeng,Wang Xuebin,et al. Synthesis and iodine-radiolabelling of peripheral benzodiazepine receptor tracer ~(131)I-CLINDE[J]. Nuclear Techniques,2006,29(10):777-781. |
| APA | Li Bin,Li Jianfeng,Wang Xuebin,&Huang Gang.(2006).Synthesis and iodine-radiolabelling of peripheral benzodiazepine receptor tracer ~(131)I-CLINDE.Nuclear Techniques,29(10),777-781. |
| MLA | Li Bin,et al."Synthesis and iodine-radiolabelling of peripheral benzodiazepine receptor tracer ~(131)I-CLINDE".Nuclear Techniques 29.10(2006):777-781. |
入库方式： OAI收割
来源：上海药物研究所
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