Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group
文献类型：期刊论文
| 作者 | ZHANG Jianxin; WANG Junxia; ZHANG Yu; ZUO Jianping ; WU Jinming; SUI Yi; LI Ying
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2006 |
| 卷号 | 41期号:1页码:65-70 |
| 关键词 | artemisinin derivatives polyethylene glycol group immunosuppressive activity higher |
| ISSN号 | 0513-4870 |
| 其他题名 | 具有免疫抑制作用的含有聚乙二醇基的青蒿素衍生物的合成 |
| 文献子类 | Article |
| 英文摘要 | Aim To search for new artemisinin derivatives with higher immunosuppressive activity. Methods Two kinds of new artemisinin derivatives containing polyethylene glycol group were synthesized from dihydroartemisinin via condensation and esterification. These compounds were assayed for their inhibitory activity on ConA-induced T cell proliferation and LPS-induced B cell proliferation. Results Twenty three new compounds（2a- 2f, 3a-3d, 4a-4f, 6a, 6b and 7a-7g）were synthesized and identified by ~H NMR and elemental analysis. Conclusion These compounds had immunosuppressive activity in vitro. Among them, the symmetrical substituted compound 2 and 6 had higher activity than mono-substituted compound 3, 4 and 7. Especially, compounds 2a -2f remarkably exhibited inhibition in comparison with artemisinin and artesunate. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2315066 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268269]  |
| 专题 | 科研条件处 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | ZHANG Jianxin,WANG Junxia,ZHANG Yu,et al. Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group[J]. Acta Pharmaceutica Sinica,2006,41(1):65-70. |
| APA | ZHANG Jianxin.,WANG Junxia.,ZHANG Yu.,ZUO Jianping.,WU Jinming.,...&LI Ying.(2006).Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group.Acta Pharmaceutica Sinica,41(1),65-70. |
| MLA | ZHANG Jianxin,et al."Synthesis and immunosuppressive activity of new artemisinin derivatives containing polyethylene glycol group".Acta Pharmaceutica Sinica 41.1(2006):65-70. |
入库方式： OAI收割
来源：上海药物研究所
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