Advances of dopamine D3 receptor in neurobiology
文献类型：期刊论文
| 作者 | He You; Jin Guozhang
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2005 |
| 卷号 | 17期号:2页码:170-175 |
| 关键词 | dopamine D3 receptor signaling pathway schizophrenia Parkinson's disease drug craving |
| ISSN号 | 1004-0374 |
| 其他题名 | 多巴胺D3受体(D3R)的神经科学新进展 |
| 文献子类 | Review |
| 英文摘要 | Dopamine is one of important neurotransmitters in brain, and is implicated in the regulation of motor activity, cognition process and drug abuse through different dopamine receptor subtypes. The function of dopamine D3 receptor (D3R), a member of D2-like receptors, has been elusive for a long time. New advances of D3R have been achieved in recently years. Activation of D3R results in the cell mitogenesis in function assay in vitro, and the signaling pathway is not typical cAMP signal. The D3R knock-out mice have also been generated. The results from these mice show D3R plays a secondary role in physiological condition. However, the role is switched to unique "buffer action" in the pathological condition, which is premised on the prevention of various neuropsychiatric disorders such as schizophrenia, dyskinesia induced by levodopa during Parkinson's disease therapy and drug craving. Therefore, D3R is an important therapeutic target. The antagonists of D3R are supposed to improve schizophrenia, while the PD patients and drag abuser will benefit from the agonists of D3R. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Neurosciences & Neurology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1925483 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268341]  |
| 专题 | 院士及顾问专家 |
| 作者单位 | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | He You,Jin Guozhang. Advances of dopamine D3 receptor in neurobiology[J]. Chinese Bulletin of Life Sciences,2005,17(2):170-175. |
| APA | He You,&Jin Guozhang.(2005).Advances of dopamine D3 receptor in neurobiology.Chinese Bulletin of Life Sciences,17(2),170-175. |
| MLA | He You,et al."Advances of dopamine D3 receptor in neurobiology".Chinese Bulletin of Life Sciences 17.2(2005):170-175. |
入库方式： OAI收割
来源：上海药物研究所
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