Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study
文献类型：期刊论文
| 作者 | Yang, Zheng4; Shao, Yong-cong3,4; Li, Shi-jiang2; Qi, Jian-lin3,4; Zhang, Mei-jie6; Hao, Wei5; Jin, Guo-zhang1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2008-07 |
| 卷号 | 29期号:7页码:781-788 |
| 关键词 | heroin addiction levo-tetrahydropalmatine abstinence rate relapse |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2008.00817.x |
| 文献子类 | Article |
| 英文摘要 | Aim: Drug addiction is a chronic brain disease with constant relapse requiring long-term treatment. New pharmacological strategies focus on the development of an effective antirelapse drug. This study examines the effects of levotetrahydropalmatine (l-THP) on reducing heroin craving and increasing the abstinence rate among heroin-dependent patients. Methods: In total, 120 heroin-dependent patients participated in the randomized, double-blinded, and placebo-controlled study using l-THP treatment. The participants remained in a ward during a 4-week period of l-THP treatment, followed by 4 weeks of observation after treatment. The patients were followed for 3 months after discharge. Outcome measures are the measured severity of the protracted abstinence withdrawal syndrome (PAWS) and the abstinence rate. Results: Four weeks of l-THP treatment significantly ameliorated the severity of PAWS, specifically, somatic syndrome, mood states, insomnia, and drug craving, in comparison to the placebo group. Based on the 3 month follow-up observation, participants who survived the initial 2 weeks of l-THP medication and remained in the trial program had a significantly higher abstinence rate of 47.8% (95% confidence interval [CI]: 33%-67%) than the 15.2% in the placebo group (95% CI: 7%-25%), according to a log-rank test (P < 0.0005). Conclusion: l-THP significantly ameliorated PAWS, especially reducing drug craving. Furthermore, it increased the abstinence rate among heroin users. These results support the potential use of l-THP for the treatment of heroin addiction. |
| WOS关键词 | COCAINE-INDUCED REINSTATEMENT ; DOPAMINE D-3 RECEPTORS ; ENHANCED BRAIN REWARD ; SEEKING BEHAVIOR ; DRUG-ADDICTION ; ANTAGONIST ; TETRAHYDROPROTOBERBERINES ; ENANTIOMERS ; STRIATUM ; RELEASE |
| 资助项目 | NIDA NIH HHS[R01 DA010214] ; NIDA NIH HHS[DA10214] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3301325 |
| WOS记录号 | WOS:000257701000002 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272868]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Hao, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA; 3.Forth Mil Med Univ, Dept Aerosp Psychol, Xian 710003, Peoples R China; 4.Beijing Inst Basic Med Sci, Beijing 100005, Peoples R China; 5.Xiangya Med Sch, Mental Hlth Inst, Changsha 410078, Hunan, Peoples R China; 6.Med Coll Wisconsin, Dept Biostat, Milwaukee, WI 53226 USA; |
| 推荐引用方式 GB/T 7714 | Yang, Zheng,Shao, Yong-cong,Li, Shi-jiang,et al. Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study[J]. ACTA PHARMACOLOGICA SINICA,2008,29(7):781-788. |
| APA | Yang, Zheng.,Shao, Yong-cong.,Li, Shi-jiang.,Qi, Jian-lin.,Zhang, Mei-jie.,...&Jin, Guo-zhang.(2008).Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study.ACTA PHARMACOLOGICA SINICA,29(7),781-788. |
| MLA | Yang, Zheng,et al."Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study".ACTA PHARMACOLOGICA SINICA 29.7(2008):781-788. |
入库方式： OAI收割
来源：上海药物研究所
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