Synthesis and evaluation of a trace for peripheral benzodiazepine receptors
文献类型：期刊论文
| 作者 | Li Bin2; Li Jian-Feng1 ; Fu Lei3; Sun Xiao-Guang2; Liu Jian-Jun2; Huang Gang2
|
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2008-01-10 |
| 卷号 | 29期号:1页码:86-89 |
| 关键词 | peripheral benzodiazepine receptor radioligand imidazol [1,2-a] pyridine |
| ISSN号 | 0251-0790 |
| 文献子类 | Article |
| 英文摘要 | The 2-iodophenyl-imidazo [1,2-a]-pyridines tlirfluoromethyl derivative (ITFZOL) was prepared to study the PBR. The [I-125] analogue was prepared via iododestannylation reaction in radiochemical yields of 75%-85% and a specific activity > 76 GBq/mu mol. After injection of [I-125] ITFZOL into mice through the tall vein, high accumulations of radioactivity were found in PBR-rich tissues such as adrenal, lung, kidney, heart, olfactory bulb and cerebellum. Per-administration of PBR-selective PK11195 displayed a significant reduction of radioactivity, suggesting a high specific binding of [I-125] ITFZOL to PBR. The biological data reveal that [I-125] ITFZOL is a potential and selective single photo emitting radioligand for PBR. |
| WOS关键词 | LIGANDS ; SPECT |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3204903 |
| WOS记录号 | WOS:000252618000018 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273004]  |
| 专题 | 科研与新药推进处 |
| 通讯作者 | Huang Gang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Nucl Med, Shanghai 200127, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Bin,Li Jian-Feng,Fu Lei,et al. Synthesis and evaluation of a trace for peripheral benzodiazepine receptors[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(1):86-89. |
| APA | Li Bin,Li Jian-Feng,Fu Lei,Sun Xiao-Guang,Liu Jian-Jun,&Huang Gang.(2008).Synthesis and evaluation of a trace for peripheral benzodiazepine receptors.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(1),86-89. |
| MLA | Li Bin,et al."Synthesis and evaluation of a trace for peripheral benzodiazepine receptors".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.1(2008):86-89. |
入库方式： OAI收割
来源：上海药物研究所
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