LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts
文献类型：期刊论文
| 作者 | Ye, Guan; Zhu, Hai-Yan; Li, Zhi-Xiong ; Ma, Chun-Hui; Fan, Ming-Song; Sun, Zhao-Lin; Huang, Cheng-Gang
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
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| 出版日期 | 2007-06 |
| 卷号 | 21期号:6页码:655-660 |
| 关键词 | LC-MS Sophora flavescens efficacy substances alkaloids |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.805 |
| 文献子类 | Article |
| 英文摘要 | Anti-DHBV (duck hepatitis B virus) activity was found in the aqueous extracts of Sophora flavescens Ait. in vivo. Liquid chromatography/electrospray ionization ion trap mass spectrometry was applied to characterize the components in duck serum after oral administration of S. flavescens extract. Oxymatrine (1), sophoranol (2), sophoridine (3) and matrine (4) were identified in the serum. Further research on the four compounds was evaluated for their antiviral activity against HBV (hepatitis B virus) in cell culture. The results suggested that oxymatrine. sophoranol and matrine were the efficacy substances for anti-HBV activity in aqueous extracts of S. flavescens Ait. Copyright (c) 2007 John Wiley & Sons, Ltd. |
| WOS关键词 | ALKALOIDS ; HEPATITIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000247337900014 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273236]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng-Gang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guan,Zhu, Hai-Yan,Li, Zhi-Xiong,et al. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts[J]. BIOMEDICAL CHROMATOGRAPHY,2007,21(6):655-660. |
| APA | Ye, Guan.,Zhu, Hai-Yan.,Li, Zhi-Xiong.,Ma, Chun-Hui.,Fan, Ming-Song.,...&Huang, Cheng-Gang.(2007).LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts.BIOMEDICAL CHROMATOGRAPHY,21(6),655-660. |
| MLA | Ye, Guan,et al."LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts".BIOMEDICAL CHROMATOGRAPHY 21.6(2007):655-660. |
入库方式： OAI收割
来源：上海药物研究所
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