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Development of huperzine A and B for treatment of Alzheimer's disease

文献类型：期刊论文

作者Bai, Donglu
刊名PURE AND APPLIED CHEMISTRY
出版日期2007-04
卷号79期号:4页码:469-479
关键词acetylcholinesterase inhibitors butyrocholinesterase inhibitors huperzine A huperzine B Alzheimer's disease dimers
ISSN号0033-4545
DOI10.1351/pac200779040469
文献子类Article; Proceedings Paper
英文摘要Recent studies have proved that huperzine A (HupA) possesses different pharmacological actions other than the inhibition of hydrolysis of ACh. These noncholinergic roles, for instance, the antagonist effect on NMDA receptor, the protection of neuronal cells against beta-amyloid, free radicals, and hypoxia-ischemia-induced injury, could be important too in Alzheimer's disease (AD) treatment. The therapeutic effects of HupA are probably based on a multitarget mechanism. By targeting dual active sites of AChE, a series of bis- and bifunctional HupB compounds with various lengths of tether were designed, synthesized, and tested for the inhibition and selectivity of AChE. The most potent bis-HupB compound exhibited increase by three orders of magnitude in AChE inhibition and two orders of magnitude in selectivity for AChE than its parent HupB.
WOS关键词ANTICHOLINESTERASE ACTIVITY ; ASYMMETRIC-SYNTHESIS ; WORKING-MEMORY ; INDUCED INJURY ; HIGHLY POTENT ; ACETYLCHOLINESTERASE ; INHIBITORS ; CHEMISTRY ; TACRINE ; E2020
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000246032800003
出版者WALTER DE GRUYTER GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/273304]  
专题院士及顾问专家
通讯作者Bai, Donglu
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Bai, Donglu. Development of huperzine A and B for treatment of Alzheimer's disease[J]. PURE AND APPLIED CHEMISTRY,2007,79(4):469-479.
APA Bai, Donglu.(2007).Development of huperzine A and B for treatment of Alzheimer's disease.PURE AND APPLIED CHEMISTRY,79(4),469-479.
MLA Bai, Donglu."Development of huperzine A and B for treatment of Alzheimer's disease".PURE AND APPLIED CHEMISTRY 79.4(2007):469-479.

入库方式： OAI收割

来源：上海药物研究所

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