Two new coumarins from Fraxinus chinensis Rexb.
文献类型：期刊论文
| 作者 | Zhang, Dong-Mei; Wang, Li-Li; Li, Jia ; Hu, Li-Hong
|
| 刊名 | JOURNAL OF INTEGRATIVE PLANT BIOLOGY
 |
| 出版日期 | 2007-02 |
| 卷号 | 49期号:2页码:218-221 |
| 关键词 | coumarins Fraxinus chinensis VEGF receptor-1 kinase |
| ISSN号 | 1672-9072 |
| DOI | 10.1111/j.1672-9072.2006.00340.x |
| 文献子类 | Article |
| 英文摘要 | The ethanol extract of the stem bark of Fraxinus chinensis Roxb. showed good inhibitory bioactivity against VEGF receptor-1 kinase (IC50: 13.8 mu g/mL). In order to find new and bioactive compounds, the chemical constituents of the stem bark of F. chinensis were investigated and two new coumarins, namely 6'-O-sinapinoyl esculin (compound 1) and 6'-O-vanillyl esculin (compound 2), together with eleven known compounds (compounds 3-13) were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimensional nuclear magnetic resonance spectral methods. The known compound, oleuropein (compound 11), exhibited moderate activity (IC50: (8.7 +/- 1.3) mu mol/L) to inhibit VEGF receptor-1 kinase. |
| WOS关键词 | GROWTH-FACTOR RECEPTOR-1 ; PROTEIN-KINASES ; INHIBITORS ; PROMOTES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2839124 |
| WOS记录号 | WOS:000243976800013 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273339]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Li-Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 210203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Natl Ctr Drug Screening, Shanghai 210203, Peoples R China 3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dong-Mei,Wang, Li-Li,Li, Jia,et al. Two new coumarins from Fraxinus chinensis Rexb.[J]. JOURNAL OF INTEGRATIVE PLANT BIOLOGY,2007,49(2):218-221. |
| APA | Zhang, Dong-Mei,Wang, Li-Li,Li, Jia,&Hu, Li-Hong.(2007).Two new coumarins from Fraxinus chinensis Rexb..JOURNAL OF INTEGRATIVE PLANT BIOLOGY,49(2),218-221. |
| MLA | Zhang, Dong-Mei,et al."Two new coumarins from Fraxinus chinensis Rexb.".JOURNAL OF INTEGRATIVE PLANT BIOLOGY 49.2(2007):218-221. |
入库方式： OAI收割
来源：上海药物研究所
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