Cytotoxic withaphysalins from Physalis minima
文献类型：期刊论文
| 作者 | Ma, Lei; Gan, Xian-Wen; He, Qing-Ping; Bai, Hai-Yun; Arfan, Mohammad; Lou, Feng-Chang; Hu, Li-Hong |
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2007 |
| 卷号 | 90期号:7页码:1406-1419 |
| ISSN号 | 0018-019X |
| DOI | 10.1002/hlca.200790143 |
| 文献子类 | Article |
| 英文摘要 | A novel withanolide, withaphysalin P (1) with a nine-membered ring, and six other new withaphysalins, 2-7, together with the three known withaphysalins 8-10 were isolated from Physalis minima L. The structures were deduced by means of spectroscopic analyses, and that of withaphysalin P (1) was confirmed by a single-crystal X-ray diffraction analysis. Plausible biosynthetic pathways were postulated (Scheme 1). All compounds were tested for their antiproliferative activities toward the human colorectal-carcinoma HCT-116 cells and human nonsmall-cell lung-cancer NCI-H460 cells (Table 4). Compounds 1-3, 7-10, 7a, and 7b displayed moderate cytotoxic activity against the two human cancer cell lines. |
| WOS关键词 | DUNALIA-BRACHYACANTHA ; VAR INDICA ; WITHANOLIDES ; LACTONES ; SKELETON |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000248388700018 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273391]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Li-Hong |
| 作者单位 | 1.China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China 2.Univ Peshawar, Inst Chem Sci, Peshawar, Pakistan 3.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Lei,Gan, Xian-Wen,He, Qing-Ping,et al. Cytotoxic withaphysalins from Physalis minima[J]. HELVETICA CHIMICA ACTA,2007,90(7):1406-1419. |
| APA | Ma, Lei.,Gan, Xian-Wen.,He, Qing-Ping.,Bai, Hai-Yun.,Arfan, Mohammad.,...&Hu, Li-Hong.(2007).Cytotoxic withaphysalins from Physalis minima.HELVETICA CHIMICA ACTA,90(7),1406-1419. |
| MLA | Ma, Lei,et al."Cytotoxic withaphysalins from Physalis minima".HELVETICA CHIMICA ACTA 90.7(2007):1406-1419. |
入库方式： OAI收割
来源：上海药物研究所
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