HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction
文献类型：期刊论文
| 作者 | Ye, Guan; Zhu, Hai-Yan; Zhao, Hao-Long; Xu, Bo; Huang, Cheng-Gang
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2006-08 |
| 卷号 | 20期号:8页码:743-747 |
| 关键词 | SPE HPLC geniposide Yin-Zhi-Ku decoction |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.590 |
| 文献子类 | Article |
| 英文摘要 | A new HPLC method for the determination of geniposide in rat serum with solid-phase extraction (SPE) for preconcentration is described. Geniposide and an internal standard (paeoniflorin) were extracted from serum by SPE using C-18 cartridges. Analysis of the extract was then performed on a reversed-phase C-18 column using acetonitrile-water (16:84, v/v) as the eluting solvent system, and UV detection at 238 nm was used to measure the analyte with a limit of quantitation about 0.1 mu g/mL. The calibration curve for geniposide was linear (r = 0.9993) in the concentration range 0.1-16.0 mu g/mL. The intra- and inter-day precision of the geniposide were determined and their RSD did not exceed 10%. The validated method has been successfully applied for pharmacokinetic studies of geniposide from rat serum after oral administration of Yin-Zhi-Ku decoction. Copyright (c) 2005 John Wiley & Sons, Ltd. |
| WOS关键词 | GENIPIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000239541300009 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273523]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Cheng-Gang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guan,Zhu, Hai-Yan,Zhao, Hao-Long,et al. HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(8):743-747. |
| APA | Ye, Guan,Zhu, Hai-Yan,Zhao, Hao-Long,Xu, Bo,&Huang, Cheng-Gang.(2006).HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction.BIOMEDICAL CHROMATOGRAPHY,20(8),743-747. |
| MLA | Ye, Guan,et al."HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction".BIOMEDICAL CHROMATOGRAPHY 20.8(2006):743-747. |
入库方式： OAI收割
来源：上海药物研究所
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