New triterpenoids from Kadsura heteroclita and their cytotoxic activity
文献类型：期刊论文
| 作者 | Wang, W; Liu, JZ; Han, J; Xu, ZR; Liu, RX; Liu, P; Wang, WX; Ma, XC; Guan, SH ; Guo, D
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2006-04 |
| 卷号 | 72期号:5页码:450-457 |
| 关键词 | Kadsura heteroclita Schizandraceae triterpenoids cytotoxic activity cyclolanostane lactone |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-2005-916263 |
| 文献子类 | Article |
| 英文摘要 | Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A - E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time from a natural source, and the six known compounds schisanlactone E (8), cycloartenone (9), schisandronic acid (10), nigranoic acid (11), changnanic acid (12) and schisanlactone B (13), respectively. The structures of these compounds were characterized by extensive 1D and 2D NMR spectral analyses. The majority of these triterpenoids showed moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL60. Among the compounds tested, heteroclitalactone D (4) showed the strongest cytotoxic activity against the HL-60 cells with an IC50 of 6.76 mu M. |
| WOS关键词 | SCHISANDRA SP ; ACID ; LACTONES ; LIGNANS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000237192200011 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273638]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, D |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China 2.Peking Univ, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, W,Liu, JZ,Han, J,et al. New triterpenoids from Kadsura heteroclita and their cytotoxic activity[J]. PLANTA MEDICA,2006,72(5):450-457. |
| APA | Wang, W.,Liu, JZ.,Han, J.,Xu, ZR.,Liu, RX.,...&Guo, D.(2006).New triterpenoids from Kadsura heteroclita and their cytotoxic activity.PLANTA MEDICA,72(5),450-457. |
| MLA | Wang, W,et al."New triterpenoids from Kadsura heteroclita and their cytotoxic activity".PLANTA MEDICA 72.5(2006):450-457. |
入库方式： OAI收割
来源：上海药物研究所
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