Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats
文献类型：期刊论文
| 作者 | Li, L ; Ye, M; Bi, KS; Guo, D
|
| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2006-01 |
| 卷号 | 20期号:1页码:95-100 |
| 关键词 | L-tetrahydropalmatine biotransformation metabolism LC-MS/MS |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.534 |
| 文献子类 | Article |
| 英文摘要 | L-Tetrahydropaimatine (L-THP) is an active alkaloid from Stephania ainiaca Diels. In order to compare the similarities and differences of microbial and mammalian metabolisms Of L-THP. the microbial transformation by Penicillium janthinellum and metabolism in rats were investigated. Biotransformation Of L-THP by Penicillium janthinellum AS 3.510 resulted in the formation of three metabolites. Their structures were identified as L-corvdalmine, L-corypalmine and 9-O-desmethyl-L-THP. respectively, by comprehensive nuclear magnetic resonance and mass spectrometry (MS) analysis. Six metabolites (M1-M6) were detected from the in vivo study in rats and three of which (L-corydalmine, L-corypalmine and 9-O-desmethyl-L-THP) were identified as the same compounds as those obtained from microbial metabolism by liquid chromatography-tandem mass spectrometry (LC-MS/ MS) analysis and comparison with reference standards obtained from microbial metabolism. The structures of the additional three metabolites were tentatively deduced as 2-O-desmethyl-L-THP and two di-O-demethylated L-THP by LC-MS/MS analysis. Time courses of microbial and rat metabolisms Of L-THP were also investigated. Copyright (c) 2005 John Wiley & Sons, Ltd. |
| WOS关键词 | MAMMALIAN METABOLISM ; MICROBIAL MODELS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000234871800014 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273696]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Guo, D |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Sci, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, L,Ye, M,Bi, KS,et al. Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(1):95-100. |
| APA | Li, L,Ye, M,Bi, KS,&Guo, D.(2006).Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats.BIOMEDICAL CHROMATOGRAPHY,20(1),95-100. |
| MLA | Li, L,et al."Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats".BIOMEDICAL CHROMATOGRAPHY 20.1(2006):95-100. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。