Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B
文献类型：期刊论文
| 作者 | Feng, S; Xia, Y; Han, DM; Zheng, CY; He, XC; Tang, XC ; Bai, DL
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2005-02-01 |
| 卷号 | 15期号:3页码:523-526 |
| 关键词 | AChE inhibitors huperzine B derivatives Bis-HupB |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2004.11.060 |
| 文献子类 | Article |
| 英文摘要 | By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB. (C) 2004 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CHOLINESTERASE INHIBITION ; ALZHEIMERS-DISEASE ; E2020 ; MICE |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000226935700006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273916]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Bai, DL |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab New Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, S,Xia, Y,Han, DM,et al. Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2005,15(3):523-526. |
| APA | Feng, S.,Xia, Y.,Han, DM.,Zheng, CY.,He, XC.,...&Bai, DL.(2005).Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,15(3),523-526. |
| MLA | Feng, S,et al."Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15.3(2005):523-526. |
入库方式： OAI收割
来源：上海药物研究所
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