PTP1B inhibitors from Ardisia japonica
文献类型：期刊论文
| 作者 | Li, YF; Hu, LH; Lou, FC; Li, J ; Shen, Q
|
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2005-02 |
| 卷号 | 7期号:1页码:13-18 |
| 关键词 | Myrsinaceae Ardisia japonica chemical constituents PTP1B inhibitor |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020310001596033 |
| 文献子类 | Article |
| 英文摘要 | In bioassay-directed isolation from the whole plant of Ardisia japonica, sixteen known compounds: chrysophanol ( 1), physcion ( 2), oleanolic acid (3), euscaphic acid ( 4), tormentic acid ( 5), quercetin ( 6), quercitrin (7), myricitrin (8), kaempferol 3-O-alpha-L-rhamnopyranoside (9), cyclamiretin A 3-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->2)-[beta-D-glucopyranosyl(1-->4)]-alpha-L-arabinopyranoside (10), (7E)-9-hydroxymegastigma-4, 7-dien-3-on-9-O-beta-D-glucopyranoside (11), bergenin (12), norbergenin (13), rutin (14), kaempferol 3,7-O-alpha-L-dirhamnopyranoside (15), (-)-epigallacatechin 3-O-gallate ( 16) were obtained. Compounds 1 - 5, 9, 11 and 14 - 16 have not been reported previously from this plant. Among these isolates, 2, 3, 6 and 12 showed moderate bioactivity against PTP1B in vitro with IC50 values of 121.50, 23.90, 28.12 and 157 muM, respectively. |
| WOS关键词 | INSULIN ACTION ; NIDDM ; ACID |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000225842200003 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273926]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, LH |
| 作者单位 | 1.Sichuan Univ, Dept Pharmaceut & Bioengn, Chengdu 610065, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.China Pharmaceut Univ, Dept Phytochem, Nanjing 210038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YF,Hu, LH,Lou, FC,et al. PTP1B inhibitors from Ardisia japonica[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2005,7(1):13-18. |
| APA | Li, YF,Hu, LH,Lou, FC,Li, J,&Shen, Q.(2005).PTP1B inhibitors from Ardisia japonica.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,7(1),13-18. |
| MLA | Li, YF,et al."PTP1B inhibitors from Ardisia japonica".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 7.1(2005):13-18. |
入库方式： OAI收割
来源：上海药物研究所
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