Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm
文献类型：期刊论文
| 作者 | Gao, C; Chen, LW; Chen, J ; Xu, XJ; Chi, ZQ
|
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2003-02 |
| 卷号 | 13期号:1页码:29-34 |
| 关键词 | cAMP-response element binding protein (CREB) ohmefentanyl stereo isomers opiates hippocampus conditioned place preference (CPP) |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/sj.cr.7290148 |
| 文献子类 | Article |
| 英文摘要 | The present study was designed to determine the changes of phosphorylation of cAMP- response element binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204) in conditioned place preference (CPP) paradigm. The results showed that mice receiving F9202 and P9204 displayed obvious CPP. They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels. The effect of F9204 was similar to morphine which effect was more potent and longer than F9202. We also examined the effects of ketamine, a noncompetitive N-mthyl-D-aspartate receptor (NR) antagonist, on morphine-, F9202- and F9204- induced CPP and phosphorylation of CREB in hippocampus. Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204. These findings suggest that alterations in the phosphorylation of CREB be relevant to opiates signaling and the development of opiates dependence. NR antagonists may interfere with opiates dependence and may have potential therapeutic implications. |
| WOS关键词 | ELEMENT-BINDING PROTEIN ; KINASE-II ; CHRONIC MORPHINE ; RAT HIPPOCAMPUS ; MOLECULAR-BASIS ; DRUG-ADDICTION ; DEPENDENCE ; PLASTICITY ; SENSITIZATION ; TRANSCRIPTION |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1220470 |
| WOS记录号 | WOS:000182597600004 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274267]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Chi, ZQ |
| 作者单位 | 1.Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Xuzhou 221002, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, C,Chen, LW,Chen, J,et al. Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm[J]. CELL RESEARCH,2003,13(1):29-34. |
| APA | Gao, C,Chen, LW,Chen, J,Xu, XJ,&Chi, ZQ.(2003).Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm.CELL RESEARCH,13(1),29-34. |
| MLA | Gao, C,et al."Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm".CELL RESEARCH 13.1(2003):29-34. |
入库方式： OAI收割
来源：上海药物研究所
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