Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats
文献类型：期刊论文
| 作者 | Ding, YM; Tang, FM; Yu, LP; Fu, Y; Zhang, GY; Jin, GZ
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-10 |
| 卷号 | 21期号:10页码:885-892 |
| 关键词 | stepholidine corpus striatum 6-hydroxydopamine in situ hybridization gene expression enkephalins dynorphins fos genes |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study that l-stepholidine (SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats. METHODS: PENK and PDYN mRNA levels were examined with in situ hybridization, and Fos expression was detected with immunocytochemistry. The data were semi-quantified with image analyzer. RESULTS: (1) Following repeated SPD treatment, the rotation was kept on high activity in the 6-OHDA-lesioned rats. (2) SPD significantly elicited Fos expression in both sides of striatum, particularly in the denervated one. Repeated administration of SPD, Fos expression declined on both sides, particularly in the intact one. (3) In the denervated striatum of 6-OHDA-lesioned rats, the PENK mRNA level was extremely increased vs that in the intact striatum. This high level of PENK mRNA was significantly reduced by 7-d treatments of SPD. SPD also reduced the level of PENK mRNA in the intact striatum. However, the level of PDYN mRNA did not show significant change in both sides of striatum after denervation or SPD treatment. CONCLUSION: In the 6-OHDA-lesioned rats, the rotation induced by SPD was kept on a high activity, which was in pace with the inducement of Fos expression and the reduction of expression of PENK mRNA in the denervated striatum. But then the lesion and SPD treatment had no remarkable effect on the expression of PDYN mRNA. |
| WOS关键词 | MESSENGER-RNA LEVELS ; DOPAMINE RECEPTOR ANTAGONISTS ; GENE-EXPRESSION ; LESIONED RATS ; ADULT-RATS ; DYNORPHIN ; BEHAVIOR ; NEURONS ; D2 ; ENKEPHALIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:510148 |
| WOS记录号 | WOS:000089725800004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274567]  |
| 专题 | 院士及顾问专家 |
| 通讯作者 | Jin, GZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Xuzhou Med Coll, Dept Biochem & Mol Biol, Xuzhou 221002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, YM,Tang, FM,Yu, LP,et al. Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(10):885-892. |
| APA | Ding, YM,Tang, FM,Yu, LP,Fu, Y,Zhang, GY,&Jin, GZ.(2000).Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats.ACTA PHARMACOLOGICA SINICA,21(10),885-892. |
| MLA | Ding, YM,et al."Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats".ACTA PHARMACOLOGICA SINICA 21.10(2000):885-892. |
入库方式： OAI收割
来源：上海药物研究所
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