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Arcuate nucleus of hypothalamus involved in analgesic action of l-THP

文献类型：期刊论文

作者Hu, JY; Jin, GZ
刊名ACTA PHARMACOLOGICA SINICA
出版日期2000-05
卷号21期号:5页码:439-444
关键词tetrahydropalmatine horseradish peroxidase arcuate nucleus PAG corpus striatum nucleus accumbens analgesia naloxone endorphins
ISSN号0253-9756
文献子类Article
英文摘要AIM: To study the role of the arcuate nucleus of hypothalamus in analgesic action of l-tetrahydropalmatine ( I-THP). METHODS: The horseradish peroxidase (HRP) retrograde tracing, HRP retrograde tracing combined with immunohistochemistry, lesion of nucleus, tail- flick test, and intra-PAG injection were used in the present study. RESULTS: HRP retrograde tracing results showed that the striatum or accumbens nucleus connect with PAG by two pathways: 1) striatum or accumbens nucleus --> arcuate nucleus --> PAG; 2) striatum or accumbens nucleus --> habenula --> PAG. It was found that neurons in the arcuate nucleus projecting to PAG were mainly beta-endorphin neurons as observed by HRP retrograde tracing combined with immuno-histochemistry. After lesion of the arcuate nucleus, the analgesic action of l-THP (40 mg.kg(-1), ip) was abolished, while lesion of the habenula had no such effect. Moreover, intra-PAG injection of naloxone (2, 3 mu g) could markedly attenuate the analgesic action of E-THP (40 mg kg-l, ip) in a dose-dependent manner. CONCLUSION: beta-Endorphin neurons in the arcuate nucleus play an important role in the analgesic action of l-THP.
WOS关键词PERIAQUEDUCTAL GRAY ; DESCENDING PATHWAY ; ACCUMBENS ; TETRAHYDROPROTOBERBERINES ; HABENULA
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000086866500011
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/274622]  
专题院士及顾问专家
通讯作者Jin, GZ
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Hu, JY,Jin, GZ. Arcuate nucleus of hypothalamus involved in analgesic action of l-THP[J]. ACTA PHARMACOLOGICA SINICA,2000,21(5):439-444.
APA Hu, JY,&Jin, GZ.(2000).Arcuate nucleus of hypothalamus involved in analgesic action of l-THP.ACTA PHARMACOLOGICA SINICA,21(5),439-444.
MLA Hu, JY,et al."Arcuate nucleus of hypothalamus involved in analgesic action of l-THP".ACTA PHARMACOLOGICA SINICA 21.5(2000):439-444.

入库方式： OAI收割

来源：上海药物研究所

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