Investigation of Inclusion Complex of Patchouli Alcohol with beta-Cyclodextrin
文献类型：期刊论文
| 作者 | Xu, Fangfang2; Yang, Qiuxia2,4; Wu, Lilan2; Qi, Rui2; Wu, Yunshan2; Li, Yucui3; Tang, Lipeng2; Guo, De-an1,2,4 ; Liu, Bo2
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2017-01-17 |
| 卷号 | 12期号:1 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0169578 |
| 文献子类 | Article |
| 英文摘要 | The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with beta-cyclodextrin (beta-CD). The interactions between patchouli alcohol and beta-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation -infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value Delta(b)G degrees was-10.8174+/-1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied. |
| WOS关键词 | POGOSTEMONIS HERBA ; CABLIN |
| 资助项目 | National Natural Science Foundation of China[81202398] ; National Natural Science Foundation of China[81302868] ; Guangdong Provincial Science and Technology Project[20136010102006] ; Guangdong Provincial Science and Technology Project[2014A020221035] ; Guangdong Provincial Science and Technology Project[2015A020211025] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2014ZHR209] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2015MS03] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2014ZH08] ; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine[YN2015QN03] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000392372300026 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275674]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Xu, Fangfang; Liu, Bo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai, Peoples R China 2.Guangzhou Univ Chinese Med, Guangdong Prov Acad Chinese Med Sci, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China; 3.Guangzhou Univ Chinese Med, Coll Chinese Med, Guangzhou, Guangdong, Peoples R China; 4.Guangdong Pharmaceut Univ, Coll Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Fangfang,Yang, Qiuxia,Wu, Lilan,et al. Investigation of Inclusion Complex of Patchouli Alcohol with beta-Cyclodextrin[J]. PLOS ONE,2017,12(1). |
| APA | Xu, Fangfang.,Yang, Qiuxia.,Wu, Lilan.,Qi, Rui.,Wu, Yunshan.,...&Liu, Bo.(2017).Investigation of Inclusion Complex of Patchouli Alcohol with beta-Cyclodextrin.PLOS ONE,12(1). |
| MLA | Xu, Fangfang,et al."Investigation of Inclusion Complex of Patchouli Alcohol with beta-Cyclodextrin".PLOS ONE 12.1(2017). |
入库方式： OAI收割
来源：上海药物研究所
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