Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice
文献类型：期刊论文
| 作者 | Hu, Pei2,3; Li, Zhixiong3 ; Chen, Mingcang3; Sun, Zhaolin3; Ling, Yun1; Jiang, Jian2; Huang, Chenggang3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2016-03-30 |
| 卷号 | 139页码:150-158 |
| 关键词 | Fucoidan ESI-Q-TOF-MS Chemical structure Sargassum fusiforme Alzheimer's disease |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2015.12.019 |
| 文献子类 | Article |
| 英文摘要 | A fucoidan, Sargassum fusiforme polysaccharide 65 (SFPS65) A, was isolated from a brown alga (S. fusiforme). SFPS65A had an estimated molecular weight of 90 kDa and showed [alpha](D)(20) - 74.3288 (c 0.05, H2O). SFPS65A is composed of fucose, galactose, xylo se, glucose, glucuronic acid, and manno se in the ratio of 19.23:9.58:6.64:1:6.52:2.57. The structural features of SFPS65A were investigated using composition analysis, methylation analysis, infrared spectrum, nuclear magnetic resonance spectroscopy, and electrospray ionization quadruple time-of-flight tandem mass spectroscopy. Results showed that SFPS65A has a main chain composed of -> 3)-beta-L Fucp (1 -> 3,4)-beta-L-Fucp (1 -> 3,4)-beta-L-Fucp (1 -> and connected with -> 3,4)-alpha-D-GlcAp-(1 ->, -> 4)-beta-D-Xylp-(1 ->, -> 4)-alpha-D-Galp-(1 ->, -> 3,6)-alpha-D-Manp-(1 -> alternately. The branches at 0-3 of the fucosyl residue and 0-3 of the hexosyl residues may include sulfate, -> 4)-beta-L-Fucp- (1 ->, beta-D-Xylp-(1 ->, and beta-D-Xylp-(1 ->. SFPS65A exhibited an activity on Alzheimer's disease in vivo in the pharmacological experiments by increasing the cognitive abilities of scopolamine-, ethanol-, and sodium nitrite-treated mice against memory deficits. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BROWN SEAWEED ; ALZHEIMERS-DISEASE ; CHOLINERGIC SYSTEM ; HIZIKIA-FUSIFORME ; MASS-SPECTROMETRY ; FUCUS-EVANESCENS ; FUCOIDAN ; ALGA ; HETEROPOLYSACCHARIDE ; QUANTITATION |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001-003] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000368097200019 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276097]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Chenggang |
| 作者单位 | 1.Jiujiang Univ, Dept Pharmaceut & Life Sci, Jiujiang 332005, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Clin Pharmacol, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hu, Pei,Li, Zhixiong,Chen, Mingcang,et al. Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice[J]. CARBOHYDRATE POLYMERS,2016,139:150-158. |
| APA | Hu, Pei.,Li, Zhixiong.,Chen, Mingcang.,Sun, Zhaolin.,Ling, Yun.,...&Huang, Chenggang.(2016).Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice.CARBOHYDRATE POLYMERS,139,150-158. |
| MLA | Hu, Pei,et al."Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice".CARBOHYDRATE POLYMERS 139(2016):150-158. |
入库方式： OAI收割
来源：上海药物研究所
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