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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

文献类型：期刊论文

作者Li, Defang1,2,3,4,5; Liu, Jin1,2,3,4; Guo, Baosheng1,2,3,4,5,6; Liang, Chao1,2,3,4,7,8; Dang, Lei1,2,3,4; Lu, Cheng3,9; He, Xiaojuan2,9; Cheung, Hilda Yeuk-Siu2,6; Xu, Liang2; Lu, Changwei2
刊名NATURE COMMUNICATIONS
出版日期2016-03
卷号7
ISSN号2041-1723
DOI10.1038/ncomms10872
文献子类Article
英文摘要Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-3p associates with both elevated serum exosomal miR-214-3p and reduced bone formation in elderly women with fractures and in ovariectomized (OVX) mice. Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation that is rescued by osteoclast-targeted antagomir-214-3p treatment. We further demonstrate that osteoclastderived exosomal miR-214-3p is transferred to osteoblasts to inhibit osteoblast activity in vitro and reduce bone formation in vivo. Moreover, osteoclast-targeted miR-214-3p inhibition promotes bone formation in ageing OVX mice. Collectively, our results suggest that osteoclast- derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation. Inhibition of miR-214-3p in osteoclasts may be a strategy for treating skeletal disorders involving a reduction in bone formation.
WOS关键词ANIMAL MICRORNAS ; CELLS ; RESORPTION ; MECHANISM ; DISEASE ; SYSTEM ; CANCER ; DIFFERENTIATION ; MICROPARTICLES ; COMMUNICATION
资助项目Ministry of Science and Technology of China[2013ZX09301307] ; Hong Kong General Research Fund[HKBU479111] ; Hong Kong General Research Fund[HKBU478312] ; Hong Kong General Research Fund[HKBU262913] ; Hong Kong General Research Fund[HKBU12102914] ; Hong Kong General Research Fund[HKBU261113] ; Hong Kong General Research Fund[HKBU212111] ; Hong Kong General Research Fund[HKBU212613] ; Hong Kong General Research Fund[CUHK14112915] ; Hong Kong General Research Fund[CUHK489213] ; Natural Science Foundation Council of China[81272045] ; Natural Science Foundation Council of China[81401833] ; Natural Science Foundation Council of China[81470072] ; Natural Science Foundation Council of China[N_HKBU435/12] ; Research Grants Council[00000000] ; Croucher Foundation[CAS14BU/CAS14201] ; Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University[RC-IRMS/12-13/02] ; Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University[RC-IRMS/13-14/02] ; Hong Kong Baptist University Strategic Development Fund[SDF13-1209-P01] ; Hong Kong Research Grants Council Early Career Scheme[489213] ; Inter-institutional Collaborative Research Scheme of Hong Kong Baptist University[RC-ICRS/14-15/01] ; Faculty Research Grant of Hong Kong Baptist University[FRG1/13-14/024] ; Faculty Research Grant of Hong Kong Baptist University[FRG2/13-14/006] ; Faculty Research Grant of Hong Kong Baptist University[FRG2/14-15/010] ; Faculty Research Grant of Hong Kong Baptist University[FRG2/14-15/063] ; China Academy of Chinese Medical Sciences[Z0252] ; China Academy of Chinese Medical Sciences[Z0293]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000371719000001
源URL[http://119.78.100.183/handle/2S10ELR8/276123]  
专题上海中药现代化研究中心
通讯作者Lu, Aiping; Zhang, Ge
作者单位1.HKBU Inst Res & Continuing Educ, Shenzhen Lab Combinatorial Cpds & Targeted Drug D, Shenzhen 518057, Peoples R China;
2.Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong 999077, Hong Kong, Peoples R China;
3.Hong Kong Baptist Univ, Sch Chinese Med, Inst Integrated Bioinfomed & Translat Sci, Hong Kong 999077, Hong Kong, Peoples R China;
4.HKBU Inst Sci & Technol, Res Grp Bone & Joint Dis, Haimen 226100, Peoples R China;
5.Kunshan Ind Technol Res Inst, Acadamecian Chen Xinzi Workroom Adv Translat Med, Kunshan RNAi Inst, Kunshan 215300, Jiangsu, Peoples R China;
6.Hong Kong Baptist Univ, Shum Yiu Foon Shum Bik Chuen Mem Ctr Canc & Infla, Hong Kong 999077, Hong Kong, Peoples R China;
7.Hunan Univ, Hong Kong Baptist Univ Branch, State Key Lab Chemo Biosensing & Chemometr, Hong Kong 999077, Hong Kong, Peoples R China;
8.Hong Kong Baptist Univ Northwestern Polytech Univ, Shenzhen 518057, Peoples R China;
9.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China;
10.City Univ Hong Kong, Dept Biol & Chem, Hong Kong 999077, Hong Kong, Peoples R China;
推荐引用方式
GB/T 7714		 Li, Defang,Liu, Jin,Guo, Baosheng,et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation[J]. NATURE COMMUNICATIONS,2016,7.
APA Li, Defang.,Liu, Jin.,Guo, Baosheng.,Liang, Chao.,Dang, Lei.,...&Zhang, Ge.(2016).Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.NATURE COMMUNICATIONS,7.
MLA Li, Defang,et al."Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation".NATURE COMMUNICATIONS 7(2016).

入库方式： OAI收割

来源：上海药物研究所

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