The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice
文献类型：期刊论文
| 作者 | Zhao, Qun1,3; Yang, Min3; Deng, Yanping3; Yu, Haitao3; Wang, Linlin3; Teng, Fukang1,3; Cho, Kenka4; Ma, Hongmei2; Wu, Peng1,3; Li, Xue3 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2015-12 |
| 卷号 | 16期号:12页码:29345-29356 |
| 关键词 | safety salvianolic acid B ginsenoside Rg1 acute toxicity repeated toxicity |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms161226176 |
| 文献子类 | Article |
| 英文摘要 | Our previous study indicated that the combination of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1), the main components of Salvia miltiorrhizae and Panax notoginseng, improves myocardium structure and ventricular function in rats with ischemia/reperfusion injury. The present study aimed to determine the safety of the combined SalB and Rg1 (SalB-Rg1) in mice. The safety of SalB-Rg1 was evaluated through acute toxicity and repeated-dose toxicity. In the acute toxicity study, the up and down procedure was carried out firstly, and then, the Bliss method was applied. In the toxicity study for seven-day repeated treatment of SalB-Rg1, forty Kunming mice were randomly divided into four groups. The intravenous median lethal dose (LD50) of the SalB-Rg1 combination was 1747 mg/kg using the Bliss method. For both the acute toxicity study and the seven-day repeated toxicity study, SalB-Rg1 did not induce significant abnormality on brain, heart, kidney, liver and lung structure at any dose based on H&E stain. There were no significant changes related to the SalB-Rg1 toxicity detected on biochemical parameters for two kinds of toxicity studies. The LD50 in mice was 1747 mg/kg, which was more than one hundred times higher than the effective dose. Both studies of acute toxicity and seven-day repeated dose toxicity indicated the safety of the SalB-Rg1 combination. |
| WOS关键词 | PANAX-NOTOGINSENG ; MILTIORRHIZA ; DANSHEN ; TOXICITY |
| 资助项目 | National Science & Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2013ZX09103002-024] ; National Natural Science Foundation of China Grants[81573646] ; Shanghai Science and Technology Development Foundation[14401900900] ; Croucher Foundation[CAS14201] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000367535600087 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276295]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Xu, Feng |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China; 2.E China Univ Sci & Technol, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo 6660162, Japan; |
| 推荐引用方式 GB/T 7714 | Zhao, Qun,Yang, Min,Deng, Yanping,et al. The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(12):29345-29356. |
| APA | Zhao, Qun.,Yang, Min.,Deng, Yanping.,Yu, Haitao.,Wang, Linlin.,...&Guo, De-An.(2015).The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(12),29345-29356. |
| MLA | Zhao, Qun,et al."The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.12(2015):29345-29356. |
入库方式： OAI收割
来源：上海药物研究所
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