Progress in Study of Clarifying The Structure and The Mechanisms That Regulate The Activity of The Proteasome
文献类型：期刊论文
| 作者 | Sun Peng; Liu Miao; Feng Li-Xing; Liu Xuan |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2015-12 |
| 卷号 | 42期号:12页码:1084-1093 |
| 关键词 | proteasome structure transcriptional regulation post-translational modification subunit assembly |
| ISSN号 | 1000-3282 |
| 文献子类 | Review |
| 英文摘要 | Proteasome is responsible for degradation of majority of the intracellular proteome and it could regulate almost all of the fundamental biological processes. Dysfunction of the proteolytic activity of the proteasome is associated with lots of diseases. Recently, several research groups have made important progress in clarifying high-resolution structure and regulating mechanisms of the proteasome. In this review, we focus on the structure of the proteasome and the mechanisms that regulate activity of the proteasome including transcriptional regulation, post-translational modification and assembly of subunits. These new findings in proteasome study will shed new light on development of new drugs for treatment of diseases related to dysfunction of the proteasome. An introduction of available proteasome inhibitors is also included in the present review. |
| WOS关键词 | YEAST 26S PROTEASOME ; 20S PROTEASOME ; MOLECULAR ARCHITECTURE ; EUKARYOTIC PROTEASOME ; DNA-DAMAGE ; SUBSTRATE ; DEGRADATION ; PROTEIN ; STRESS ; POLYUBIQUITIN |
| 资助项目 | Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2014ZX09301-306-003] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5588731 |
| WOS记录号 | WOS:000367202700002 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276303]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu Xuan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Peng,Liu Miao,Feng Li-Xing,et al. Progress in Study of Clarifying The Structure and The Mechanisms That Regulate The Activity of The Proteasome[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2015,42(12):1084-1093. |
| APA | Sun Peng,Liu Miao,Feng Li-Xing,&Liu Xuan.(2015).Progress in Study of Clarifying The Structure and The Mechanisms That Regulate The Activity of The Proteasome.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,42(12),1084-1093. |
| MLA | Sun Peng,et al."Progress in Study of Clarifying The Structure and The Mechanisms That Regulate The Activity of The Proteasome".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 42.12(2015):1084-1093. |
入库方式： OAI收割
来源：上海药物研究所
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