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Quantitative and qualitative determination of LiuweiDihuang preparations by ultra high performance liquid chromatography in dual-wavelength fingerprinting mode and random forest

文献类型：期刊论文

作者Qiu, Yixing1,2; Huang, Jianhua1,3; Jiang, Xingming1; Chen, Yang1; Liu, Yang1; Zeng, Rong1; Shehla, Nuzhat1; Liu, Qiang1; Liao, Duanfang2; Guo, Dean1,4
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2015-11
卷号38期号:21页码:3720-3726
关键词Dual-wavelength fingerprinting Liquid chromatography LiuweiDihuang Quality control Random forest
ISSN号1615-9306
DOI10.1002/jssc.201500560
文献子类Article
英文摘要The classical traditional Chinese formulation LiuweiDihuang, shown to have clinical efficacy for "nourishing kidney-yin" in traditional Chinese medicine, has been used for thousands of years in China. Little attention, however, has been paid to quality control methods for this formulation. Hence, a rapid and sensitive analytical technique is urgently needed for the evaluation of LiuweiDihuang preparations to assess its quality and pharmacological functionality. In this study, an ultra high performance liquid chromatography dual-wavelength method was developed to simultaneously determine 11 constituents in LiuweiDihuang preparations. This robust approach provided a fast and comprehensive quantitative determination of the major bioactive markers within LiuweiDihuang preparations. To distinguish four dosage forms of LiuweiDihuang preparations, a random forest technique was applied on the spectrometric fingerprint data obtained. This combination approach of chromatographic techniques and data analyses might serve as a rapid and efficient tool to ensure the quality of LiuweiDihuang preparations and other Chinese medicinal formulations and can support quality control and scientific research into the pharmacological potential for these formulations.
WOS关键词LIUWEI DIHUANG DECOCTION ; DIABETIC ENCEPHALOPATHY ; BIOACTIVE CONSTITUENTS ; STREPTOZOTOCIN ; RATS ; PILLS ; ACID ; DAD ; MS
资助项目program for the Changsha Science & Technology Bureau[K1205019-31] ; Ministry of Education of Overseas Returnees Start-up Find for Scientific Research[2013693] ; Graduate Student Innovation Project of Hunan Province[CX2014B369]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000363480800007
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/276348]  
专题上海中药现代化研究中心
通讯作者Wang, Wei
作者单位1.Hunan Univ Chinese Med, Sch Pharm, Sino Luxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China;
2.Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat Chinese Mat Med, Changsha, Hunan, Peoples R China;
3.Cent S Univ, Res Ctr Modernizat Tradit Chinese Med, Changsha, Hunan, Peoples R China;
4.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Qiu, Yixing,Huang, Jianhua,Jiang, Xingming,et al. Quantitative and qualitative determination of LiuweiDihuang preparations by ultra high performance liquid chromatography in dual-wavelength fingerprinting mode and random forest[J]. JOURNAL OF SEPARATION SCIENCE,2015,38(21):3720-3726.
APA Qiu, Yixing.,Huang, Jianhua.,Jiang, Xingming.,Chen, Yang.,Liu, Yang.,...&Wang, Wei.(2015).Quantitative and qualitative determination of LiuweiDihuang preparations by ultra high performance liquid chromatography in dual-wavelength fingerprinting mode and random forest.JOURNAL OF SEPARATION SCIENCE,38(21),3720-3726.
MLA Qiu, Yixing,et al."Quantitative and qualitative determination of LiuweiDihuang preparations by ultra high performance liquid chromatography in dual-wavelength fingerprinting mode and random forest".JOURNAL OF SEPARATION SCIENCE 38.21(2015):3720-3726.

入库方式： OAI收割

来源：上海药物研究所

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