Identification and structural elucidation of steroidal saponins from the root of Paris polyphylla by HPLC-ESI-QTOF-MS/MS
文献类型：期刊论文
| 作者 | Ling, Yun1; Fu, Zhiwen2,3; Zhang, Qing1 ; Xu, Lingling1; Liao, Liang1
|
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2015-10-02 |
| 卷号 | 29期号:19页码:1798-1803 |
| 关键词 | Paris polyphylla separation HPLC-ESI-QTOF-MS MS |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2015.1007137 |
| 文献子类 | Article |
| 英文摘要 | The root of Paris polyphylla (RPP) is widely used as a traditional Chinese medicine for a long time due to the good properties of heat-clearing and detoxicating, detumescence, sedation, acesodyne and haemostasis. To clarify on the bioactive substances and ensure the safety in clinical medication, a feasible and accurate strategy was developed by applying the high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight-mass spectrometry (HPLC-ESI-QTOF-MS/MS). Separation was performed an Agilent poroshell 120 EC-C18 column (2.7x100mm, i.d., 2.7m) with 0.1% formic acid aqueous solution and acetonitrile as the mobile phase under gradient conditions. Based on the proposed strategy, 30 constituents, mainly including steroidal saponins, were characterised or tentatively identified, 2 of which were the first to be reported as the potential new steroidal saponins in RPP. In conclusion, the HPLC-ESI-QTOF-MS/MS is a feasible and credible technique to separate and identify steroidal saponins from botanical extracts. |
| WOS关键词 | GLYCOSIDES |
| 资助项目 | National Natural Science Foundation of China[31460073] ; National Natural Science Foundation of China[31260044] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000360458600004 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276373]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Ling, Yun |
| 作者单位 | 1.Jiujiang Univ, Dept Pharmaceut & Life Sci, Jiujiang 332005, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Dept Clin Pharmacol, Shuguang Hosp, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ling, Yun,Fu, Zhiwen,Zhang, Qing,et al. Identification and structural elucidation of steroidal saponins from the root of Paris polyphylla by HPLC-ESI-QTOF-MS/MS[J]. NATURAL PRODUCT RESEARCH,2015,29(19):1798-1803. |
| APA | Ling, Yun,Fu, Zhiwen,Zhang, Qing,Xu, Lingling,&Liao, Liang.(2015).Identification and structural elucidation of steroidal saponins from the root of Paris polyphylla by HPLC-ESI-QTOF-MS/MS.NATURAL PRODUCT RESEARCH,29(19),1798-1803. |
| MLA | Ling, Yun,et al."Identification and structural elucidation of steroidal saponins from the root of Paris polyphylla by HPLC-ESI-QTOF-MS/MS".NATURAL PRODUCT RESEARCH 29.19(2015):1798-1803. |
入库方式： OAI收割
来源：上海药物研究所
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