Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium
文献类型：期刊论文
| 作者 | Shen, Sida; Chen, Yijia; Lei, Min ; Hu, Lihong
|
| 刊名 | MONATSHEFTE FUR CHEMIE
 |
| 出版日期 | 2015-09 |
| 卷号 | 146期号:9页码:1571-1580 |
| 关键词 | 2-Cyanobenzaldehyde Isoindolin-1-imine Multi-component reactions Green chemistry |
| ISSN号 | 0026-9247 |
| DOI | 10.1007/s00706-015-1449-0 |
| 文献子类 | Article |
| 英文摘要 | A catalyst-free, one-pot method has been developed for the synthesis of isoindolin-1-imine derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and active methylene compound (1,3-dimethylbarbituric acid, Meldrum's acid, 5,5-dimethylcyclohexane-1,3-dione, and 1,3-cyclohexanedione). The efficient and convenient reaction provides the corresponding products from various substrates at room temperature in aqueous medium with excellent yields (90-98 %) via easy purification. The straightforward procedure is a valid contribution to the methodology for the synthesis of isoindolin-1-imine derivatives. |
| WOS关键词 | NMDA RECEPTOR ANTAGONISTS ; KNOEVENAGEL CONDENSATION ; MELDRUMS ACID ; PART 2 ; ALDEHYDES ; 2-CYANOBENZALDEHYDE ; AMINES |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000359272500021 |
| 出版者 | SPRINGER WIEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276427]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Sida,Chen, Yijia,Lei, Min,et al. Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium[J]. MONATSHEFTE FUR CHEMIE,2015,146(9):1571-1580. |
| APA | Shen, Sida,Chen, Yijia,Lei, Min,&Hu, Lihong.(2015).Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium.MONATSHEFTE FUR CHEMIE,146(9),1571-1580. |
| MLA | Shen, Sida,et al."Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium".MONATSHEFTE FUR CHEMIE 146.9(2015):1571-1580. |
入库方式： OAI收割
来源：上海药物研究所
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