Methylhexanamine is not detectable in Pelargonium or Geranium species and their essential oils: A multi-centre investigation
文献类型：期刊论文
| 作者 | ElSohly, Mahmoud A.4,5,6,7; Gul, Waseem4,5,6; Tolbert, Candice4; ElSohly, Kareem M.4,5; Murphy, Timothy P.4; Avula, Bharathi6; Chittiboyina, Amar G.6; Wang, Mei6; Khan, Ikhlas A.2,5,6; Yang, Min3 |
| 刊名 | DRUG TESTING AND ANALYSIS
 |
| 出版日期 | 2015-07 |
| 卷号 | 7期号:7页码:645-654 |
| 关键词 | MHA Pelargonium species Geranium species |
| ISSN号 | 1942-7603 |
| DOI | 10.1002/dta.1726 |
| 文献子类 | Article |
| 英文摘要 | In an earlier study, we developed two sensitive and reliable procedures for gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of methylhexaneamine (MHA) in P. graveolens plant materials and volatile oils. None of the analyzed plant materials or oils showed any detectable levels of MHA which was further substantiated by high resolution liquid chromatography-quantum time of flight-mass spectrometry (LC-QTOF-MS) analysis with a limit of detection of 10ppb. However, other laboratories (two studies) reported the presence of MHA in some samples of P. graveolens and pelargonium oil acquired by the investigators from China. Because of the controversy of whether Pelargonium species or pelargonium oil contains MHA, it was recommended that splits of multiple samples be analyzed by different laboratories. In this investigation, multiple plant materials and oil samples were collected from around the world. These samples were submitted to four different sites for analysis. All sites adopted a similar extraction method. All the analysis sites used LC-MS/MS or LC-QTOF-MS and detection limit was set close to the 10ng/mL as previously reported. A total of 18 plant samples belonging to 6 different Pelargonium species and 9 oils from different locations around the world were split among 4 different analytical laboratories for analysis (each lab received the same samples). None of the laboratories detected MHA in any of the samples at or around the 10ppb detection level of the procedure used. Copyright (c) 2014 John Wiley & Sons, Ltd. |
| WOS关键词 | SUPPLEMENTS |
| 资助项目 | FDA HHS[U01 FD004246] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000358611000011 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276476]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | ElSohly, Mahmoud A. |
| 作者单位 | 1.Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China 2.Univ Mississippi, Sch Pharm, Div Pharmacognosy, Dept BioMol Sci, University, MS 38677 USA; 3.Shanghai Inst Mat Med, Shanghai, Peoples R China; 4.ELI, Oxford, MS 38655 USA; 5.PSI, Oxford, MS 38655 USA; 6.Univ Mississippi, Sch Pharm, Dept BioMol Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA; 7.Univ Mississippi, Sch Pharm, Div Pharmaceut, Dept BioMol Sci, University, MS 38677 USA; |
| 推荐引用方式 GB/T 7714 | ElSohly, Mahmoud A.,Gul, Waseem,Tolbert, Candice,et al. Methylhexanamine is not detectable in Pelargonium or Geranium species and their essential oils: A multi-centre investigation[J]. DRUG TESTING AND ANALYSIS,2015,7(7):645-654. |
| APA | ElSohly, Mahmoud A..,Gul, Waseem.,Tolbert, Candice.,ElSohly, Kareem M..,Murphy, Timothy P..,...&Su, Juan.(2015).Methylhexanamine is not detectable in Pelargonium or Geranium species and their essential oils: A multi-centre investigation.DRUG TESTING AND ANALYSIS,7(7),645-654. |
| MLA | ElSohly, Mahmoud A.,et al."Methylhexanamine is not detectable in Pelargonium or Geranium species and their essential oils: A multi-centre investigation".DRUG TESTING AND ANALYSIS 7.7(2015):645-654. |
入库方式： OAI收割
来源：上海药物研究所
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