Synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives by Suzuki-Miyaura reaction
文献类型：期刊论文
| 作者 | Lei, Min ; Gan, Xianwen; Zhao, Kun; Chen, Anfeng; Hu, Lihong
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2015-05-27 |
| 卷号 | 71期号:21页码:3325-3332 |
| 关键词 | 3,4-Disubstituted-furan-2(5H)-one Suzuki-Miyaura reaction 3,4-Dibromo-furan-2(5H)-one Potassium benzyltrifluoroborate Regioselectivity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2015.03.106 |
| 文献子类 | Article |
| 英文摘要 | A facile and efficient method for the synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives using PdCl2(dppf)(2) as catalyst via the Suzuki Miyaura reaction was reported. 3,4-Dibenzylfuran-2(5H)-ones were synthesized through the coupling reaction of 3,4-dibromo-furan-2(5H)-one and potassium benzyltrifluoroborates in the presence of Pdcl(2)(dppf)(2)/Cs2CO3. However, regioselective product 4-benzyl-3bromofuran-2(5H)-ones were obtained under PdCl2(dppf)(2)/K2CO3 conditions. Furthermore, 4-benzyl-3-bromofuran-2(5H)-ones could react with another molecule of potassium benzyltrifluoroborates or phenylboronic acids to form 3,4-asymmetric disubstituted furan-2(5H)-ones. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ASYMMETRIC-SYNTHESIS ; ARCTIGENIN ; CELLS ; LIGNANS ; HALIDES |
| 资助项目 | National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81473110] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000355031000018 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276520]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Lihong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Min,Gan, Xianwen,Zhao, Kun,et al. Synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives by Suzuki-Miyaura reaction[J]. TETRAHEDRON,2015,71(21):3325-3332. |
| APA | Lei, Min,Gan, Xianwen,Zhao, Kun,Chen, Anfeng,&Hu, Lihong.(2015).Synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives by Suzuki-Miyaura reaction.TETRAHEDRON,71(21),3325-3332. |
| MLA | Lei, Min,et al."Synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives by Suzuki-Miyaura reaction".TETRAHEDRON 71.21(2015):3325-3332. |
入库方式： OAI收割
来源：上海药物研究所
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