Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues
文献类型：期刊论文
| 作者 | Guo, Jing1,2; Xu, Chenghui2; Xue, Rui2; Jiang, Weixin1; Wu, Bin2; Huang, Chenggang2
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2015-05 |
| 卷号 | 38期号:5页码:598-603 |
| 关键词 | Anemarrhena asphodeloides Timosaponins Xanthones Analogues Cytotoxic activity |
| ISSN号 | 0253-6269 |
| DOI | 10.1007/s12272-014-0431-4 |
| 文献子类 | Article |
| 英文摘要 | Seven steroidal saponins (1-7) and two xanthones (8, 9) were isolated from the rhizomes of Anemarrhena asphodeloides. Then in order to discover more analogues, which may possess good biological activity, the structural modifications of 2 and 9 were performed by acid hydrolysis and acetylation. Consequently, one novel steroidal saponin (2d, timosaponin BII-d), three compounds (2c, 2e and 2f) which were also the new products prepared by the diluted acid hydrolysis of 3 by our group previously, and four known compounds (2a, 2b, 9a and 9b) were obtained. The structures were elucidated by analyses of NMR and MS data. All the compounds were evaluated for their cytotoxicities against BEL-7402, HT-29, HeLa and MDA-MB-468 cell lines in vitro by Sulforhodamine protein coloration method. Compounds 1, 2, 2b, 4-6, 9a and 9b showed certain anti-proliferative activities against the four cell lines, in which compounds 2, 4 and 9b exhibited especially more potent activities. The structure-activity relationships of these compounds were simply discussed. |
| WOS关键词 | STEROIDAL SAPONINS ; PLATELET-AGGREGATION ; HYDROLYSIS |
| 资助项目 | National Natural Science Foundation of China[81274055] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000354299800004 |
| 出版者 | PHARMACEUTICAL SOC KOREA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276550]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Chenggang |
| 作者单位 | 1.Harbin Univ Commerce, Harbin 150076, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Media, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Guo, Jing,Xu, Chenghui,Xue, Rui,et al. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues[J]. ARCHIVES OF PHARMACAL RESEARCH,2015,38(5):598-603. |
| APA | Guo, Jing,Xu, Chenghui,Xue, Rui,Jiang, Weixin,Wu, Bin,&Huang, Chenggang.(2015).Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues.ARCHIVES OF PHARMACAL RESEARCH,38(5),598-603. |
| MLA | Guo, Jing,et al."Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues".ARCHIVES OF PHARMACAL RESEARCH 38.5(2015):598-603. |
入库方式： OAI收割
来源：上海药物研究所
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