Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
文献类型：期刊论文
| 作者 | Liu, Rongxia2,3; Heiss, Elke H.2; Sider, Nadine2; Schinkovitz, Andreas1; Groblacher, Barbara3; Guo, Dean3 ; Bucar, Franz1; Bauer, Rudolf1; Dirsch, Verena M.2; Atanasov, Atanas G.2
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| 刊名 | MOLECULAR NUTRITION & FOOD RESEARCH
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| 出版日期 | 2015-05 |
| 卷号 | 59期号:5页码:843-852 |
| 关键词 | Ginger Heme oxygenase-1 Nrf2 [6]-Shogaol Vascular smooth muscle cell |
| ISSN号 | 1613-4125 |
| DOI | 10.1002/mnfr.201400791 |
| 文献子类 | Article |
| 英文摘要 | Scope: Vascular smooth muscle cell (VSMC) proliferation is involved in the pathogenesis of cardiovascular disease, making the identification of new counteracting agents and their mechanisms of action relevant. Ginger and its constituents have been reported to improve cardiovascular health, but no studies exist addressing a potential interference with VSMC proliferation. Methods and results: The dichloromethane extract of ginger inhibited VSMC proliferation when monitored by resazurin metabolic conversion (IC50 = 2.5 mu g/mL). The examination of major constituents from ginger yielded [6]-shogaol as the most active compound (IC50 = 2.7 mu M). In the tested concentration range [6]-shogaol did not exhibit cytotoxicity toward VSMC and did not interfere with endothelial cell proliferation. [6]-shogaol inhibited DNA synthesis and induced accumulation of the VSMC in the G(0)/G(1) cell-cycle phase accompanied with activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/HO-1 pathway. Since [6]-shogaol lost its antiproliferative activity in the presence of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX, HO-1 induction appears to contribute to the antiproliferative effect. Conclusion: This study demonstrates for the first time inhibitory potential of ginger constituents on VSMC proliferation. The presented data suggest that [6]-shogaol exerts its antiproliferative effect through accumulation of cells in the G(0)/G(1) cell-cycle phase associated with activation of the Nrf2/HO-1 pathway. |
| WOS关键词 | DRUG-ELUTING STENTS ; ZINGIBER-OFFICINALE ROSCOE ; LIQUID-CHROMATOGRAPHY ; HEME OXYGENASE-1 ; IN-VIVO ; QUANTITATIVE-ANALYSIS ; SIGNAL TRANSDUCER ; MASS-SPECTROMETRY ; PGE(2) PRODUCTION ; TRANSCRIPTION 3 |
| 资助项目 | European Union Seventh Framework Programme (EU-FP7) Marie Curie Fellowship[00000000] ; Vienna University "Back-to-Research Grant" program[00000000] ; Austrian Science Fund (FWF)[S10704/S10705] ; Austrian Science Fund (FWF) (NFN-project "Drugs from Nature Targeting Inflammation")[P25971-B23] ; Austrian Science Fund (FWF) (NFN-project "Drugs from Nature Targeting Inflammation")[P23317-B11] |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000354240800002 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276552]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Atanasov, Atanas G. |
| 作者单位 | 1.Graz Univ, Dept Pharmacognosy, Inst Pharmaceut Sci, Graz, Austria 2.Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol,Shanghai I, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Rongxia,Heiss, Elke H.,Sider, Nadine,et al. Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2015,59(5):843-852. |
| APA | Liu, Rongxia.,Heiss, Elke H..,Sider, Nadine.,Schinkovitz, Andreas.,Groblacher, Barbara.,...&Atanasov, Atanas G..(2015).Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation.MOLECULAR NUTRITION & FOOD RESEARCH,59(5),843-852. |
| MLA | Liu, Rongxia,et al."Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation".MOLECULAR NUTRITION & FOOD RESEARCH 59.5(2015):843-852. |
入库方式： OAI收割
来源：上海药物研究所
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