Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica
文献类型：期刊论文
| 作者 | Xu, Xing-Yu; Sun, Peng; Guo, De-An ; Liu, Xuan; Liu, Jun-Hua; Hu, Li-Hong
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015-03 |
| 卷号 | 101页码:218-223 |
| 关键词 | Inula japonica Thunb Sesquiterpene lactone dimer Biomimetic transformation Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2015.01.011 |
| 文献子类 | Article |
| 英文摘要 | Two new sesquiterpene lactone dimers, neojaponicone B (1) and inulanolide E (2) along with five known sesquiterpene lactone dimers (3-7, resp.) were isolated from the aerial parts of Inula japonica Thunb. The chemical structures of 1 and 2 were elucidated by detailed spectroscopic analysis. The relative configuration of 2 was confirmed by biomimetic transformation from the known sesquiterpene lactone dimer inulanolide A (3). The cytotoxicities of the isolated sesquiterpene lactone dimers were evaluated against 6T-CEM and Jurkat cell lines. All compounds showed potent cytotoxicities with IC50 value of 22-5.9 mu m. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | A-D ; THUNB ; LINEARIIFOLIA ; CONSTITUENTS ; CELLS ; NO |
| 资助项目 | National Natural Science Foundation of China[81273397] ; National Natural Science Foundation of China[81402811] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; China Postdoctoral Science Foundation[2014M550255] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000352252700027 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276617]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Jun-Hua |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xing-Yu,Sun, Peng,Guo, De-An,et al. Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica[J]. FITOTERAPIA,2015,101:218-223. |
| APA | Xu, Xing-Yu,Sun, Peng,Guo, De-An,Liu, Xuan,Liu, Jun-Hua,&Hu, Li-Hong.(2015).Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica.FITOTERAPIA,101,218-223. |
| MLA | Xu, Xing-Yu,et al."Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica".FITOTERAPIA 101(2015):218-223. |
入库方式： OAI收割
来源：上海药物研究所
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