中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

文献类型:期刊论文

作者Deng, Yanping3; Zhang, Tingting1,3; Teng, Fukang1,3; Li, Defang3; Xu, Feng1; Cho, Kenka2; Xu, Jinghua1; Yin, Jun1; Zhang, Li1,3; Liu, Qian1
刊名JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
出版日期2015-02
卷号78期号:2页码:114-120
关键词acute myocardial infarction ginsenoside Rb1 ginsenoside Rg1 Panax notoginseng salvianolic acid B Salvia miltiorrhiza
ISSN号1726-4901
DOI10.1016/j.jcma.2014.10.001
文献子类Article
英文摘要Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction. Copyright (C) 2014 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
WOS关键词PANAX-NOTOGINSENG ; FUFANG-DANSHEN ; MILTIORRHIZA ; ANGIOGENESIS ; MECHANISMS ; COMPONENTS ; SAPONINS ; QUALITY ; RADIX
资助项目National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2013ZX09103002-024] ; National Natural Science Foundation of China[81173587] ; Shanghai Science and Technology Development Foundation[14401900900] ; 12th 5-Year National Science and Technology Support Program[2012BAI29B06] ; National High Technology Research and Development Program ("863" Program) of China[SS2013AA09002]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:000351246200007
出版者ELSEVIER TAIWAN
源URL[http://119.78.100.183/handle/2S10ELR8/276647]  
专题上海中药现代化研究中心
通讯作者Jiang, Baohong
作者单位1.Shenyang Pharmaceut Univ, Shenyang, Peoples R China;
2.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo, Japan
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714
Deng, Yanping,Zhang, Tingting,Teng, Fukang,et al. Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2015,78(2):114-120.
APA Deng, Yanping.,Zhang, Tingting.,Teng, Fukang.,Li, Defang.,Xu, Feng.,...&Jiang, Baohong.(2015).Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,78(2),114-120.
MLA Deng, Yanping,et al."Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 78.2(2015):114-120.

入库方式: OAI收割

来源:上海药物研究所

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