Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells
文献类型：期刊论文
| 作者 | Lei, Min ; Gan, Xianwen; Zhao, Kun; Yu, Qiang; Hu, Lihong
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 25期号:3页码:435-437 |
| 关键词 | Arctigenin (ATG) Natural product Glucose starvation 4-Amino-4-dehydroxylarctigenin Bioisosterism |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2014.12.061 |
| 文献子类 | Article |
| 英文摘要 | The natural product arctigenin (ATG) demonstrated preferential cytotoxicity to cancer cells under glucose starvation. A series of 4-amino-4-dehydroxylarctigenin derivatives based on lead compound ATG were designed and synthesized by bioisosteric modifications. Their cytotoxicities were evaluated in glucose-starved A549 tumor cells and the results indicated that the 4-amino-4-dehydroxylarctigenin showed more potent cytotoxicity than arctigenin, and the further substituent group on 4-amino would result in the cytotoxicities decreased significantly. 4-Substituted-arctigenin could selectively target on glucose-starved A549 tumor cells which provide an alternative strategy for anticancer drug development with minimal normal tissue toxicity. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CANCER-CELLS ; NUTRIENT DEPRIVATION ; ARCTIGENIN ; TOLERANCE ; (-)-ARCTIGENIN ; STARVATION ; ELIMINATE ; AGENT |
| 资助项目 | National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81473110] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000347901700002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276660]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Hu, Lihong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Min,Gan, Xianwen,Zhao, Kun,et al. Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(3):435-437. |
| APA | Lei, Min,Gan, Xianwen,Zhao, Kun,Yu, Qiang,&Hu, Lihong.(2015).Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(3),435-437. |
| MLA | Lei, Min,et al."Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.3(2015):435-437. |
入库方式： OAI收割
来源：上海药物研究所
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