Fragmentation patterns study of iridoid glycosides in Fructus Gardeniae by HPLC-Q/TOF-MS/MS
文献类型：期刊论文
| 作者 | Fu, Zhiwen1,2; Xue, Rui2; Li, Zhixiong2 ; Chen, Mingcang2; Sun, Zhaolin2; Hu, Yiyang1; Huang, Chenggang2
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| 刊名 | BIOMEDICAL CHROMATOGRAPHY
 |
| 出版日期 | 2014-12 |
| 卷号 | 28期号:12页码:1795-1807 |
| 关键词 | Fragmentation patterns iridoid glycosides Fructus Gardeniae HPLC-Q TOF-MS MS |
| ISSN号 | 0269-3879 |
| DOI | 10.1002/bmc.3223 |
| 文献子类 | Article |
| 英文摘要 | Iridoid glycosides (IGs), the major constituents in Fructus Gardeniae, have demonstrated various pharmacological activities, but there is no systematic chemical profile of IGs in Fructus Gardeniae in the published literature until now. Therefore, it is imperative that a rapid and sensitive high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-Q/TOF-MS/MS) method is established for comprehensive characterization of IGs in Fructus Gardeniae. Firstly, the fragmentation patterns of six known IGs were investigated and proposed and further concluded the diagnostic fragment ions and characteristic fragmentation pathways. Then, based on the summarized fragmentation patterns and the known compounds in the literatures, the other IGs in Fructus Gardeniae were identified successively. As a result, a total of 20 IGs were identified, of which three pairs of epimers were structurally characterized and differentiated. More importantly, one compound, the isoshanzhiside methyl ester, was tentatively identified as a new compound. The results of this study demonstrate the superiority of HPLC-MS with a high-resolution mass spectrometer for the rapid and sensitive structural elucidation of the multiple groups of constituents in Fructus Gardeniae. Copyright (c) 2014 John Wiley & Sons, Ltd. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; TIME-OF-FLIGHT ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; IDENTIFICATION ; CONSTITUENTS |
| 资助项目 | Program of Science and Technology Commission of Shanghai Municipality[13401900303] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000345212600028 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276817]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, Chenggang |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Dept Clin Pharmacol, Shuguang Hosp, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Fu, Zhiwen,Xue, Rui,Li, Zhixiong,et al. Fragmentation patterns study of iridoid glycosides in Fructus Gardeniae by HPLC-Q/TOF-MS/MS[J]. BIOMEDICAL CHROMATOGRAPHY,2014,28(12):1795-1807. |
| APA | Fu, Zhiwen.,Xue, Rui.,Li, Zhixiong.,Chen, Mingcang.,Sun, Zhaolin.,...&Huang, Chenggang.(2014).Fragmentation patterns study of iridoid glycosides in Fructus Gardeniae by HPLC-Q/TOF-MS/MS.BIOMEDICAL CHROMATOGRAPHY,28(12),1795-1807. |
| MLA | Fu, Zhiwen,et al."Fragmentation patterns study of iridoid glycosides in Fructus Gardeniae by HPLC-Q/TOF-MS/MS".BIOMEDICAL CHROMATOGRAPHY 28.12(2014):1795-1807. |
入库方式： OAI收割
来源：上海药物研究所
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