Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions
文献类型：期刊论文
| 作者 | Chen, Fanglei; Lei, Min ; Hu, Lihong
|
| 刊名 | SYNTHESIS-STUTTGART
 |
| 出版日期 | 2014-12 |
| 卷号 | 46期号:23页码:3199-3206 |
| 关键词 | tabersonine palladium catalysis Suzuki-Miyaura cross-coupling reaction Heck reaction Sonogashira cross-coupling reaction |
| ISSN号 | 0039-7881 |
| DOI | 10.1055/s-0034-1378659 |
| 文献子类 | Article |
| 英文摘要 | A series of C-10-substituted tabersonine analogues have been synthesized via palladium-catalyzed cross-coupling reactions. To be specific, tabersonine reacted with NIS in TFA to generate the 10-iodotabersonine, which participated in palladium-catalyzed or palladium/copper co-catalyzed cross-coupling reactions, such as Suzuki-Miyaura cross-coupling reaction, Heck reaction, and Sonogashira cross-coupling reaction, to afford C-10 tabersonine analogues. These protocols provide the possibility of introducing substituents with structural diversity and complexity into the C-10 of tabersonine for the pharmacological activity screening. |
| WOS关键词 | VINBLASTINE-TYPE ALKALOIDS ; NATURAL-PRODUCTS ; INDOLE ALKALOIDS ; ASPIDOSPERMA ALKALOIDS ; SONOGASHIRA REACTIONS ; DRUG DISCOVERY ; RAPID ACCESS ; BIOSYNTHESIS ; DERIVATIVES ; VINDOLINE |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000345329100006 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276823]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fanglei,Lei, Min,Hu, Lihong. Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions[J]. SYNTHESIS-STUTTGART,2014,46(23):3199-3206. |
| APA | Chen, Fanglei,Lei, Min,&Hu, Lihong.(2014).Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions.SYNTHESIS-STUTTGART,46(23),3199-3206. |
| MLA | Chen, Fanglei,et al."Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions".SYNTHESIS-STUTTGART 46.23(2014):3199-3206. |
入库方式： OAI收割
来源：上海药物研究所
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