Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
文献类型：期刊论文
| 作者 | Hou, Yujun6; Wang, Ying1,2; Zhao, Jian6 ; Li, Xiaohang6; Cui, Jin6; Ding, Jianqing1; Zeng, Xianglu6; Ling, Yun4; Shen, Xiaoheng3; Chen, Shengdi1
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| 刊名 | PLOS ONE
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| 出版日期 | 2014-11-11 |
| 卷号 | 9期号:11 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0111215 |
| 文献子类 | Article |
| 英文摘要 | Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced A beta levels, retarded A beta amyloidosis and reduced A beta-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced A beta generation, whereas AT and PRP exerted neuroprotective effects against A beta. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease. |
| WOS关键词 | ALZHEIMERS-DISEASE ; MOUSE MODEL ; MEMORY DEFICITS ; TRANSGENIC MICE ; GAMMA-SECRETASE ; IN-VIVO ; BETA ; DROSOPHILA ; BT-11 ; RAT |
| 资助项目 | National Natural Science Foundation of China[31371419] ; Chinese Academy of Sciences[KSCX2-EW-Q-1-01] ; Chinese Academy of Sciences[KSCX2-YW-R-252] ; National Science and Technology[2012BAI10B03] ; Ministry of Science and Technology[2011CB910202] ; Shanghai Municipal Commission for Science and Technology[13401900600] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000345250400015 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276840]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Zhao, Jian |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Inst Neurol, Shanghai 200030, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200030, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Tradit Chinese Med, Shanghai 200030, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 5.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hou, Yujun,Wang, Ying,Zhao, Jian,et al. Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits[J]. PLOS ONE,2014,9(11). |
| APA | Hou, Yujun.,Wang, Ying.,Zhao, Jian.,Li, Xiaohang.,Cui, Jin.,...&Pei, Gang.(2014).Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits.PLOS ONE,9(11). |
| MLA | Hou, Yujun,et al."Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits".PLOS ONE 9.11(2014). |
入库方式： OAI收割
来源：上海药物研究所
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