Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis
文献类型：期刊论文
| 作者 | Yang, Zhiyou3; Liu, Zhihui3; Jiang, Baohong2 ; Teng, Fukang2,3; Wang, Yu1; Han, Na3; Guo, Dean2; Yin, Jun3
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2014-09-12 |
| 卷号 | 84页码:417-424 |
| 关键词 | Dihydrobenzophenanthridine alkaloids Corydalis ambigua var. amurensis X-ray diffraction Enantiomers Antimyocardial hypoxia |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2014.07.043 |
| 文献子类 | Article |
| 英文摘要 | Ten new scarce dihydrobenzophenanthridine alkaloids, including seven monomers, ambidalmines A(1/2), B-1/2-E (1(a/b), 2(a/b),-5) and three dimers, ambidimerines F-1 (6a), F-2 (6b) and F-3 (6c), were isolated from the tubers of Corydalis ambigua var. amurensis. All of these compounds were discovered in the forms of enantiomers. The structures were elucidated based on extensive spectroscopic analysis, with absolute configurations of the enantiomeric compounds assigned by single-crystal X-ray diffraction analysis, circular dichroism (CD) and optical rotations. Bioactivity evaluation showed that compounds 1a, 2a, 2b and 6b exhibit comparable protective effects on hypoxic H9C2 cells. (C) 2014 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | MYOCARDIAL-ISCHEMIA INJURY ; BENZOPHENANTHRIDINE ALKALOIDS ; CONSTITUENTS ; CARDIOPROTECTION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000341464500038 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276904]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Yin, Jun |
| 作者单位 | 1.Chinese Peoples Liberat Army 463 Hosp, Shenyang 110042, Peoples R China 2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dev & Utilizat Key Lab Northeast Plant Mat, Shenyang 110016, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Zhiyou,Liu, Zhihui,Jiang, Baohong,et al. Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,84:417-424. |
| APA | Yang, Zhiyou.,Liu, Zhihui.,Jiang, Baohong.,Teng, Fukang.,Wang, Yu.,...&Yin, Jun.(2014).Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,84,417-424. |
| MLA | Yang, Zhiyou,et al."Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 84(2014):417-424. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。