Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin
文献类型：期刊论文
| 作者 | Chen, Hu2; Lei, Min1 ; Hu, Lihong1,2
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-09-02 |
| 卷号 | 70期号:35页码:5626-5631 |
| 关键词 | Indole Aryl halide C-N coupling reaction Metformin Ullmann-type reaction |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2014.06.080 |
| 文献子类 | Article |
| 英文摘要 | Ullmann-type C-N coupling reaction has been developed for the synthesis of 1-aryl indole derivatives by indoles and aryl halides in the presence of CuI/metformin (CuI/Met) in DMF. This method is very easy, rapid, and high yielding reaction for the synthesis of 1-aryl indoles. In particular, the metformin, which is used as ligand, is inexpensive and nontoxic that is considered to be relatively environmentally benign. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NITROGEN-CONTAINING HETEROCYCLES ; N-ARYLATION ; C-N ; HETEROARYL HALIDES ; EFFICIENT LIGAND ; AMINES ; NUCLEOPHILES ; SYSTEM ; CUO ; ANTAGONISTS |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000340336000032 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276910]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 2.E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Hu,Lei, Min,Hu, Lihong. Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin[J]. TETRAHEDRON,2014,70(35):5626-5631. |
| APA | Chen, Hu,Lei, Min,&Hu, Lihong.(2014).Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin.TETRAHEDRON,70(35),5626-5631. |
| MLA | Chen, Hu,et al."Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin".TETRAHEDRON 70.35(2014):5626-5631. |
入库方式： OAI收割
来源：上海药物研究所
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