New triterpenic acids from Uncaria rhynchophylla: Chemistry, NO-inhibitory activity, and tandem mass spectrometric analysis
文献类型：期刊论文
| 作者 | Zhang, Yi-bei; Yang, Wen-zhi; Yao, Chang-liang; Feng, Rui-hong; Yang, Min; Guo, De-an ; Wu, Wan-ying
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-07 |
| 卷号 | 96页码:39-47 |
| 关键词 | Uncaria rhynchophylla Uncarinic acid NO-inhibitory effect Tandem mass spectrometric fragmentation |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2014.04.004 |
| 文献子类 | Article |
| 英文摘要 | Five new oleanane and ursane type triterpenes, namely uncarinic acids F-J (1-5), together with six known triterpenic acids (6-11) were isolated from the stems and hooks of Uncaria rhynchophylla. Structure elucidation of 1-5 was based on the integrated analyses of high-resolution MS data, 1D (H-1 NMR,C-13 NMR, DEPT) and 2D (HSQC, HMBC, ROESY) NMR spectra. Compounds 4, 10, and 11 exhibited weak inhibitory effects on LPS-induced NO production in RAW264.7 cells (with IC50 1.48, 7.01, and 1.89 mu M, respectively) with dexamethasone (IC50 0.04 mu M) and quercetin (IC50 0.86 mu M) as the positive controls. 19-OH substituted oleanane triterpenic acids (1, 2, 5, 8) were prone to eliminate CH2O3, whereas those ursane-type encompassing 19-OH (3, 6, 7, 9, 4) were featured by preferred cleavage of H2O while performing the negative collision-induced MS/MS fragmentation on an LTQ/Orbitrap mass spectrometer. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | NITRIC-OXIDE ; CELLS ; TOMENTOSA ; PLANT |
| 资助项目 | National Science and Technology Major Project for Major Drug Development[2013ZX09508104] ; Traditional Chinese Medicine Industry Research Special Project[201307002] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing program of the People's Republic of China[2011ZX09307-002-03] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000338979200006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277001]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Wu, Wan-ying |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi-bei,Yang, Wen-zhi,Yao, Chang-liang,et al. New triterpenic acids from Uncaria rhynchophylla: Chemistry, NO-inhibitory activity, and tandem mass spectrometric analysis[J]. FITOTERAPIA,2014,96:39-47. |
| APA | Zhang, Yi-bei.,Yang, Wen-zhi.,Yao, Chang-liang.,Feng, Rui-hong.,Yang, Min.,...&Wu, Wan-ying.(2014).New triterpenic acids from Uncaria rhynchophylla: Chemistry, NO-inhibitory activity, and tandem mass spectrometric analysis.FITOTERAPIA,96,39-47. |
| MLA | Zhang, Yi-bei,et al."New triterpenic acids from Uncaria rhynchophylla: Chemistry, NO-inhibitory activity, and tandem mass spectrometric analysis".FITOTERAPIA 96(2014):39-47. |
入库方式： OAI收割
来源：上海药物研究所
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