Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives
文献类型：期刊论文
| 作者 | Ma, Fei2; Ma, Lei2; Lei, Min1 ; Hu, Lihong1
|
| 刊名 | MONATSHEFTE FUR CHEMIE
 |
| 出版日期 | 2014-06 |
| 卷号 | 145期号:6页码:1035-1041 |
| 关键词 | Aldehyde Amine 1H-Indole-2-carboxylic acid Mannich reaction |
| ISSN号 | 0026-9247 |
| DOI | 10.1007/s00706-014-1171-3 |
| 文献子类 | Article |
| 英文摘要 | A facile and efficient method for the synthesis of 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives via a two-step reaction has been developed. The starting materials of 1H-indole-2-carboxylic acid, aldehyde, and amine are mixed and refluxed in ethanol to generate Mannich products, which are dehydrated in the presence of 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumto form the desired products, 1,2-dihydropyrrolo[3,4-b] indol-3(4H)-ones. |
| WOS关键词 | INDOLE-HETEROCYCLES ; OXIDATION ; HYDROGENATION |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000337046500021 |
| 出版者 | SPRINGER WIEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277053]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ma, Fei,Ma, Lei,Lei, Min,et al. Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives[J]. MONATSHEFTE FUR CHEMIE,2014,145(6):1035-1041. |
| APA | Ma, Fei,Ma, Lei,Lei, Min,&Hu, Lihong.(2014).Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives.MONATSHEFTE FUR CHEMIE,145(6),1035-1041. |
| MLA | Ma, Fei,et al."Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives".MONATSHEFTE FUR CHEMIE 145.6(2014):1035-1041. |
入库方式： OAI收割
来源：上海药物研究所
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