Structural investigation and immunological activity of a heteropolysaccharide from Sargassum fusiforme
文献类型：期刊论文
| 作者 | Hu, Pei1,2; Xue, Rui1; Li, Zhixiong1 ; Chen, Mingcang1; Sun, Zhaolin1; Jiang, Jian2; Huang, Chenggang1
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| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2014-05-22 |
| 卷号 | 390页码:28-32 |
| 关键词 | Heteropolysaccharide ESI-QTOF-MS Chemical structure Sargassum fusiforme |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2014.02.027 |
| 文献子类 | Article |
| 英文摘要 | A heteropolysaccharide was isolated from the brown alga, Sargassum fusiforme. The heteropolysaccharide was estimated to have a molecular weight of 11 kDa and showed a [alpha](20)(D) -62.2420 (c 0.05, H2O). SFPS65-B comprised galactose, glucose, mannose, fucose, and galacturonic acid at a ratio of 3.04: 1: 1.15: 2.82: 6.51. Its structural features were investigated using composition analysis, methylation analysis, IR, NMR spectroscopy, and ESI-Q-TOF MS spectroscopy. Results showed that SFPS65-B contained the backbone of -> 4)-alpha-GalAp-(1 -> 4)-alpha-Hexp-(1 -> 4)-alpha-GalAp-(1 -> 4)-alpha-Fucp-(1 -> 4)-alpha-GalAp-(1 ->. The sulfated unit and terminal fucose residues were attached onto the backbone through the O-2 of some galactose residues. Results also showed that SFPS65-B had a good effect on thymus and spleen indices at a dose of 100 mg/kg upon immunosuppression in cyclophosphamide-treated mice. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HIZIKIA-FUSIFORME ; BROWN SEAWEED ; IN-VIVO ; POLYSACCHARIDE ; GLYCOSAMINOGLYCAN ; FUCOIDAN ; WALL |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2012ZX09301001-003] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000335510200004 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277071]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Jiang, Jian |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Clin Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Pei,Xue, Rui,Li, Zhixiong,et al. Structural investigation and immunological activity of a heteropolysaccharide from Sargassum fusiforme[J]. CARBOHYDRATE RESEARCH,2014,390:28-32. |
| APA | Hu, Pei.,Xue, Rui.,Li, Zhixiong.,Chen, Mingcang.,Sun, Zhaolin.,...&Huang, Chenggang.(2014).Structural investigation and immunological activity of a heteropolysaccharide from Sargassum fusiforme.CARBOHYDRATE RESEARCH,390,28-32. |
| MLA | Hu, Pei,et al."Structural investigation and immunological activity of a heteropolysaccharide from Sargassum fusiforme".CARBOHYDRATE RESEARCH 390(2014):28-32. |
入库方式： OAI收割
来源：上海药物研究所
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