Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis
文献类型：期刊论文
| 作者 | Chen, Xu-Bing1,2; Chen, Guang-Yong1; Liu, Jun-Hua2; Lei, Min2 ; Meng, Yu-Hui2; Guo, De-An2; Liu, Xuan2; Hu, Li-Hong2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-04 |
| 卷号 | 94页码:88-93 |
| 关键词 | Hemsleya amabilis Cucurbitaceae Triterpenoid Cytotoxicity HeLa cell |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2014.01.014 |
| 文献子类 | Article |
| 英文摘要 | Two new cucurbitane triterpenoids, 7 beta-hydroxycucurbitacin F-25-O-acetate (1) and 2 beta,3 beta,20 (S),26,27-pentahydroxy-16 alpha,23(S)-epoxycucurbita-5,24-dien-11-one (2) along with eleven known cucurbitane triterpenoids (3-13, resp.) were isolated from the rhizomes of Hemsleya amabilis Diels. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated cucurbitane triterpenoids were evaluated against the HeLa human cancer cell lines. Hemslecin A (5), the main ingredient of H. amabilis, exhibited the significant cytotoxicity with IC50 value of 0389 mu M. (C) 2014 Elsevier B.V. All rights reserved. |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000335608700011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277127]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Liu, Xuan |
| 作者单位 | 1.Dali Univ, Coll Pharm, Dali 671000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Xu-Bing,Chen, Guang-Yong,Liu, Jun-Hua,et al. Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis[J]. FITOTERAPIA,2014,94:88-93. |
| APA | Chen, Xu-Bing.,Chen, Guang-Yong.,Liu, Jun-Hua.,Lei, Min.,Meng, Yu-Hui.,...&Hu, Li-Hong.(2014).Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis.FITOTERAPIA,94,88-93. |
| MLA | Chen, Xu-Bing,et al."Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis".FITOTERAPIA 94(2014):88-93. |
入库方式： OAI收割
来源：上海药物研究所
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