Anti-depressive activities and biotransformation of timosaponin B-III and its derivatives
文献类型：期刊论文
| 作者 | Jiang, WeiXin1; Guo, Jing1,2; Xue, Rui2; Zh, KaiCheng2; Li, ZhiXiong2 ; Chen, MingCang2; Huang, ChengGang2
|
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 28期号:18页码:1446-1453 |
| 关键词 | timosaponin B-III biotransformation beta-glucosidase anti-depressive activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2014.910663 |
| 文献子类 | Article |
| 英文摘要 | Timosaponin B-III (TB-III) is a steroidal saponin isolated from the rhizome of Anemarrhenae asphodeloides (Liliaceae). The biotransformation of TB-III by beta-glucosidase was investigated. Three biotransformation products were isolated and their structures were identified as timosaponin B-III-a (M1), (20R,25S)-5 beta-spirostane-3 beta-ol-3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-galacopyanoside (M2) and timosaponin AIII (M3). Then the four compounds were evaluated for their anti-depressive activity in mice by the open field test, tail suspension test and forced swimming test. As a result, TB-III, M1 and M3 exhibited modest anti-depressive activity. Structure-activity relationships were investigated and the preliminary conclusions are summarised as follows: the glycosyl at C-3 and C-26 can increase the activity, the double bond between C-20 and C-22 might be important for the anti-depressive activity, the R-configuration at C-22 and S-configuration at C-20 are necessary for its anti-depressive activity. |
| WOS关键词 | MODEL |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2012ZX09301001-001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000340273000005 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277276]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Huang, ChengGang |
| 作者单位 | 1.Harbin Univ Commerce, Harbin 150076, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Media, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, WeiXin,Guo, Jing,Xue, Rui,et al. Anti-depressive activities and biotransformation of timosaponin B-III and its derivatives[J]. NATURAL PRODUCT RESEARCH,2014,28(18):1446-1453. |
| APA | Jiang, WeiXin.,Guo, Jing.,Xue, Rui.,Zh, KaiCheng.,Li, ZhiXiong.,...&Huang, ChengGang.(2014).Anti-depressive activities and biotransformation of timosaponin B-III and its derivatives.NATURAL PRODUCT RESEARCH,28(18),1446-1453. |
| MLA | Jiang, WeiXin,et al."Anti-depressive activities and biotransformation of timosaponin B-III and its derivatives".NATURAL PRODUCT RESEARCH 28.18(2014):1446-1453. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。