Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS
文献类型：期刊论文
| 作者 | Tian, Xiaoting; Li, Zhixiong ; Lin, Yunfei; Chen, Mingcang; Pan, Guoyu; Huang, Chenggang
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| 刊名 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
 |
| 出版日期 | 2014-01 |
| 卷号 | 406期号:3页码:841-849 |
| 关键词 | Magnoflorine Cortex phellodendri decoction Berberine Interaction Pharmacokinetics (PK) |
| ISSN号 | 1618-2642 |
| DOI | 10.1007/s00216-013-7530-9 |
| 文献子类 | Article |
| 英文摘要 | Magnoflorine, an aporphine alkaloid in Cortex phellodendri, is increasingly attracting research attention because of its antidiabetic effects. However, at present, little information on its pharmacokinetics (PK) in vivo is available. In this study, a sensitive, rapid, and selective method was developed to determine the magnoflorine content in rat plasma using liquid chromatography-tandem mass spectrometry. Following liquid-liquid extraction, the calibration curve showed good linearity within the concentration range of 2.93 to 1,500 ng ml(-1). The intra- and inter-day precisions were all below 7.8 %, and the accuracy ranged from 94.9 to 103.4 %. The method was successfully applied in investigating the PK of magnoflorine in rats. The compound had low bioavailability, a high absorption rate, and a high elimination rate. However, area under the curve, T (1/2), and MRT increased approximately twofold when the same dosage of the compound was administered in a C. phellodendri decoction (20.8 g kg(-1)). Moreover, T (max) was prolonged from 0.3 to 3.33 h. Furthermore, a comparison of coadministration of the mixture group, magnoflorine (40 mg kg(-1)) and berberine (696.4 mg kg(-1)), with the C. phellodendri decoction group, revealed that no statistical difference (P > 0.05) was found in the parameter AUC, and certain similar changes in the PK trend to the herbal medicine group were also observed. These results suggested that oral administration of the herbal medicine decreased the absorption and elimination rates of magnoflorine and increased its bioavailability. Berberine played a significant role in interacting with magnoflorine and in affecting the PK profiles of magnoflorine in the C. phellodendri decoction group. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; TINOSPORA-CORDIFOLIA ; MASS-SPECTROMETRY ; RAT PLASMA ; APORPHINE ALKALOIDS ; COPTIDIS-RHIZOMA ; MAJOR ALKALOIDS ; PHARMACOKINETICS ; IDENTIFICATION ; JATRORRHIZINE |
| 资助项目 | State Key Program of National Science Foundation of China[81030065] ; National Science Foundation of China[81302836] ; Major National Science and Technology Programs[2012ZX09301001-006] ; Major National Science and Technology Programs[2012ZX09302003] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000329625800018 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277318]  |
| 专题 | 药物安全性评价中心 上海中药现代化研究中心 |
| 通讯作者 | Pan, Guoyu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Xiaoting,Li, Zhixiong,Lin, Yunfei,et al. Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2014,406(3):841-849. |
| APA | Tian, Xiaoting,Li, Zhixiong,Lin, Yunfei,Chen, Mingcang,Pan, Guoyu,&Huang, Chenggang.(2014).Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,406(3),841-849. |
| MLA | Tian, Xiaoting,et al."Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406.3(2014):841-849. |
入库方式： OAI收割
来源：上海药物研究所
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