Synthesis of benzo-annulated 1,3-oxazine derivatives through the multi-component reaction of arynes with N-heteroaromatics and aldehydes or ketones
文献类型：期刊论文
| 作者 | Liu, Peng1; Lei, Min2 ; Hu, Lihong1,2
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2013-12-02 |
| 卷号 | 69期号:48页码:10405-10413 |
| 关键词 | Aryne N-Heteroaromatic compound 1,3-Oxazine Multi-component reactions Cyclization |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2013.09.092 |
| 文献子类 | Article |
| 英文摘要 | A multi-component reaction involving arynes, N-heteroaromatic compounds (including pyridine, quinoline, and isoquinoline), and aldehydes or ketones for the synthesis of benzo-annulated 1,3-oxazine derivatives has been described. The whole process is carried out under mild conditions and furnishes the desired products in 35-85% yields. Furthermore, regioselectivity and diastereoselectivity can be observed when using 3-OMe aryne precursor in this reaction. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TERMINAL ALKYNES ; POLYSUBSTITUTED PYRIDINES ; 3-COMPONENT ; ISOCYANIDES ; ISOQUINOLINES ; ARYLATION ; NITROGEN ; ACIDS |
| 资助项目 | National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000328521700028 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277339]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Lei, Min |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; 2.Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Peng,Lei, Min,Hu, Lihong. Synthesis of benzo-annulated 1,3-oxazine derivatives through the multi-component reaction of arynes with N-heteroaromatics and aldehydes or ketones[J]. TETRAHEDRON,2013,69(48):10405-10413. |
| APA | Liu, Peng,Lei, Min,&Hu, Lihong.(2013).Synthesis of benzo-annulated 1,3-oxazine derivatives through the multi-component reaction of arynes with N-heteroaromatics and aldehydes or ketones.TETRAHEDRON,69(48),10405-10413. |
| MLA | Liu, Peng,et al."Synthesis of benzo-annulated 1,3-oxazine derivatives through the multi-component reaction of arynes with N-heteroaromatics and aldehydes or ketones".TETRAHEDRON 69.48(2013):10405-10413. |
入库方式： OAI收割
来源：上海药物研究所
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