Characterization of the Constituents Absorbed in Rats After Oral Administration of Fructus Gardeniae Effective Fraction
文献类型：期刊论文
| 作者 | Wang, Xiaojuan1,3; Li, Zhixiong1 ; Wu, Bin1; Shi, Yujing2; Guo, Shanshan2; Ji, Yubin3; Cui, Xiaolan2; Huang, Chenggang1
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| 刊名 | ASIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2013-10 |
| 卷号 | 25期号:14页码:7899-7903 |
| 关键词 | Fructus gardeniae HPLC-MSn Iridoid glycosides Urine Serum |
| ISSN号 | 0970-7077 |
| DOI | 10.14233/ajchem.2013.14681 |
| 文献子类 | Article |
| 英文摘要 | Fructus gardeniae (Chinese herbal name is Zhi Zi) is widely used as a traditional Chinese medicine (TCM) for treating various diseases. The research discovered the iridoid glycosides that extracted and isolated from fructus gardeniae have antiviral activity. However, its bioactive constituents have remained unknown. In the present study, a systematic method based on high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-MSn) techniques was developed to identify the absorbed constituents in rats after oral administration of target fraction. By comparing their MS data with those of authentic compounds and published data, a total of five compounds [deacetyl asperulosidic methyl ester (1); gardenoside (2); scandoside methyl ester (3); genipin gentiobioside (4) and geniposide(5)] were identified in the target fraction. In addition, we identified five iridoid glucosides and one of their metabolite in rat urine samples, four iridoid glucosides and one of their metabolite in rat serum samples after administration, respectively. This provides an accurate profile of the composition of bioactive compounds responsible for the antiinfluenza properties and builds a solid bottom for future research on its mechanism. |
| WOS关键词 | IONIZATION MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; IRIDOID GLYCOSIDES ; JASMINOIDES ELLIS ; IDENTIFICATION ; METABOLITES ; TECHNOLOGY ; URINE |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09103-373] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000325096400056 |
| 出版者 | ASIAN JOURNAL OF CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277437]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Cui, Xiaolan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Insitute Mat Med, Shanghai 201203, Peoples R China; 2.China Acad Chinese Med Sci, Inst Chinese Med, Beijing 100029, Peoples R China; 3.Harbin Univ Commerce, Harbin 150076, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaojuan,Li, Zhixiong,Wu, Bin,et al. Characterization of the Constituents Absorbed in Rats After Oral Administration of Fructus Gardeniae Effective Fraction[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(14):7899-7903. |
| APA | Wang, Xiaojuan.,Li, Zhixiong.,Wu, Bin.,Shi, Yujing.,Guo, Shanshan.,...&Huang, Chenggang.(2013).Characterization of the Constituents Absorbed in Rats After Oral Administration of Fructus Gardeniae Effective Fraction.ASIAN JOURNAL OF CHEMISTRY,25(14),7899-7903. |
| MLA | Wang, Xiaojuan,et al."Characterization of the Constituents Absorbed in Rats After Oral Administration of Fructus Gardeniae Effective Fraction".ASIAN JOURNAL OF CHEMISTRY 25.14(2013):7899-7903. |
入库方式： OAI收割
来源：上海药物研究所
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