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Cytotoxic cardenolides from the root bark of Calotropis gigantea

文献类型：期刊论文

作者You, Hanyun1; Lei, Min2; Song, Weibin1; Chen, Hu1; Meng, Yuhui2; Guo, Dean2; Liu, Xuan2; Hu, Lihong1,2
刊名STEROIDS
出版日期2013-10
卷号78期号:10页码:1029-1034
关键词Antitumor agent Calotropis gigantea Asclepiadaceae Cardenolide Cytotoxicity
ISSN号0039-128X
DOI10.1016/j.steroids.2013.06.002
文献子类Article
英文摘要Six new cardenolides (1, 2 and 11-14), along with ten known ones, were isolated from the root bark of Calotropis gigantea. The structural determination was accomplished by the 1D- and 2D-NMR spectrum as well as ESIMS analysis. The isolated compounds were evaluated for their in vitro growth inhibitory activity against human A549 and Hela cell lines. The results suggested that some of these cardenolides (compounds 1, 6, and 8) displayed potent cytotoxicities. (C) 2013 Elsevier Inc. All rights reserved.
WOS关键词CARDIAC-GLYCOSIDES ; ASCLEPIAS-CURASSAVICA ; PROCERA ; PRINCIPLES ; LEAVES ; CELLS ; DRUG
资助项目National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:000324443500009
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/277450]  
专题上海中药现代化研究中心
通讯作者Lei, Min
作者单位1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;
2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 You, Hanyun,Lei, Min,Song, Weibin,et al. Cytotoxic cardenolides from the root bark of Calotropis gigantea[J]. STEROIDS,2013,78(10):1029-1034.
APA You, Hanyun.,Lei, Min.,Song, Weibin.,Chen, Hu.,Meng, Yuhui.,...&Hu, Lihong.(2013).Cytotoxic cardenolides from the root bark of Calotropis gigantea.STEROIDS,78(10),1029-1034.
MLA You, Hanyun,et al."Cytotoxic cardenolides from the root bark of Calotropis gigantea".STEROIDS 78.10(2013):1029-1034.

入库方式： OAI收割

来源：上海药物研究所

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