Identification of the Major Components of Resina Draconis Extract and Their Metabolites in Rat Urine by LC-ESI-MS (n)
文献类型：期刊论文
| 作者 | Liu, Fang1,2; Wu, Bin2; Xiao, Wei3; Wang, Zhenzhong3; Sun, Zhaolin2; Yin, Jun1; Huang, Chenggang2
|
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2013-09 |
| 卷号 | 76期号:17-18页码:1131-1139 |
| 关键词 | LC-ESI-MSn Resina Draconis extract (RDE) Major components Metabolites |
| ISSN号 | 0009-5893 |
| DOI | 10.1007/s10337-013-2473-z |
| 文献子类 | Article |
| 英文摘要 | The aim of our study was to employ a liquid chromatography coupled with electrospray ionization multistage tandem mass spectrometry (LC-ESI-MS (n) ) method for the identification of the major components of Resina Draconis extract (RDE) and their metabolites in rat urine. Based on the above, 18 compounds were tentatively identified from the RDE. Among them, 4 compounds were unambiguously characterized by the comparison of the retention time and mass spectra with those of reference compounds and 14 compounds were tentatively identified by comparing the mass spectra with those of literature. In vivo, 21 compounds, including 13 parent compounds and 8 metabolites, were detected in rat urine after oral administration of RDE. The results may be helpful for future research on traditional Chinese medicine. |
| WOS关键词 | DRACAENA-COCHINCHINENSIS ; DRAGONS BLOOD ; RESVERATROL ; PTEROSTILBENE |
| 资助项目 | National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001-001] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2011ZX09201-201-20] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000323373400009 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277490]  |
| 专题 | 上海中药现代化研究中心 |
| 通讯作者 | Yin, Jun |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fang,Wu, Bin,Xiao, Wei,et al. Identification of the Major Components of Resina Draconis Extract and Their Metabolites in Rat Urine by LC-ESI-MS (n)[J]. CHROMATOGRAPHIA,2013,76(17-18):1131-1139. |
| APA | Liu, Fang.,Wu, Bin.,Xiao, Wei.,Wang, Zhenzhong.,Sun, Zhaolin.,...&Huang, Chenggang.(2013).Identification of the Major Components of Resina Draconis Extract and Their Metabolites in Rat Urine by LC-ESI-MS (n).CHROMATOGRAPHIA,76(17-18),1131-1139. |
| MLA | Liu, Fang,et al."Identification of the Major Components of Resina Draconis Extract and Their Metabolites in Rat Urine by LC-ESI-MS (n)".CHROMATOGRAPHIA 76.17-18(2013):1131-1139. |
入库方式： OAI收割
来源：上海药物研究所
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